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Your search keyword '"Islander, Ulrika"' showing total 7 results
Start Over Author "Islander, Ulrika" Publisher bioscientifica
7 results on '"Islander, Ulrika"'

1. Physiological levels of estradiol limit murine osteoarthritis progression

Author

Corciulo, Carmen, primary, Scheffler, Julia M, additional, Humeniuk, Piotr, additional, Del Carpio Pons, Alicia, additional, Stubelius, Alexandra, additional, Von Mentzer, Ula, additional, Drevinge, Christina, additional, Barrett, Aidan, additional, Wüstenhagen, Sofia, additional, Poutanen, Matti, additional, Ohlsson, Claes, additional, Lagerquist, Marie K, additional, and Islander, Ulrika, additional

Published
2022
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2. A tissue-specific role of membrane-initiated ERα signaling for the effects of SERMs

Author

Gustafsson, Karin L, primary, Movérare-Skrtic, Sofia, additional, Farman, Helen H, additional, Engdahl, Cecilia, additional, Henning, Petra, additional, Nilsson, Karin H, additional, Scheffler, Julia M, additional, Sehic, Edina, additional, Islander, Ulrika, additional, Levin, Ellis, additional, Ohlsson, Claes, additional, and Lagerquist, Marie K, additional

Published
2022
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3. Roles of activating functions 1 and 2 of estrogen receptor α in lymphopoiesis

Author

Andersson, Annica, primary, Törnqvist, Anna E, additional, Moverare-Skrtic, Sofia, additional, Bernardi, Angelina I, additional, Farman, Helen H, additional, Chambon, Pierre, additional, Engdahl, Cecilia, additional, Lagerquist, Marie K, additional, Windahl, Sara H, additional, Carlsten, Hans, additional, Ohlsson, Claes, additional, and Islander, Ulrika, additional

Published
2018
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4. Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment

Author

Gustafsson, Karin, primary, Farman, Helen, additional, Lionikaite, Vikte, additional, Wu, Jianyao, additional, Henning, Petra, additional, Andersson, Annica, additional, Islander, Ulrika, additional, Bernardi, Angelina, additional, Windahl, Sara, additional, Skrtic, Sofia, additional, Sjogren, Klara, additional, Koskela, Antti, additional, Tuukkanen, Juha, additional, Krust, Andree, additional, Chambon, Pierre, additional, Ohlsson, Claes, additional, and Lagerquist, Marie, additional

Published
2016
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7. Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral density.

Author

Grahnemo L, Jochems C, Andersson A, Engdahl C, Ohlsson C, Islander U, and Carlsten H

Subjects
Animals, Bone and Bones drug effects, Dexamethasone pharmacology, Female, Femur drug effects, Lymphocytes drug effects, Mice, Mice, Inbred C57BL, Mice, SCID, Osteogenesis drug effects, Up-Regulation drug effects, X-Ray Microtomography, Bone Density drug effects, Glucocorticoids pharmacology, Lymphocytes physiology
Abstract

Treatment with anti-inflammatory glucocorticoids is associated with osteoporosis. Many of the treated patients are postmenopausal women, who even without treatment have an increased risk of osteoporosis. Lymphocytes have been shown to play a role in postmenopausal and arthritis-induced osteoporosis, and they are targeted by glucocorticoids. The aim of this study was to investigate the mechanisms behind effects of glucocorticoids on bone during health and menopause, focusing on lymphocytes. Female C57BL/6 or SCID mice were therefore sham-operated or ovariectomized and 2 weeks later treatment with dexamethasone (dex), the nonsteroidal anti-inflammatory drug carprofen, or vehicle was started and continued for 2.5 weeks. At the termination of experiments, femurs were phenotyped using peripheral quantitative computed tomography and high-resolution micro-computed tomography, and markers of bone turnover were analyzed in serum. T and B lymphocyte populations in bone marrow and spleen were analyzed by flow cytometry. Dex-treated C57BL/6 mice had increased trabecular bone mineral density, but lower cortical content and thickness compared with vehicle-treated mice. The dex-treated mice also had lower levels of bone turnover markers and markedly decreased numbers of spleen T and B lymphocytes. In contrast, these effects could not be repeated when mice were treated with the nonsteroidal anti-inflammatory drug carprofen. In addition, dex did not increase trabecular bone in ovariectomized SCID mice lacking functional T and B lymphocytes. In contrast to most literature, the results from this study indicate that treatment with dex increased trabecular bone density, which may indicate that this effect is associated with corticosteroid-induced alterations of the lymphocyte populations., (© 2015 The authors.)

Published
2015
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