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22 results on '"Per Dahlqvist"'

1. Doctors, teach your adrenal insufficiency patients well: provide them with a European Emergency Card!

Author

Johan G Beun, Pia Burman, Olle Kämpe, Eystein S Husebye, Stephanie Hahner, Jette Kristensen, Alida Noordzij, and Per Dahlqvist

Subjects
adrenal insufficiency, patient education, medical alert card, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Adrenal insufficiency is a life-threatening condition requiring chronic glucocorticoid replacement therapy, as well as stress adaptation to prevent adrenal crises. To increase patients’ self-sustainability, education on how to tackle an ad renal crisis is crucial. All patients should carry the European Emergency Card.

Published
2022
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2. Confounding effects of liquorice, hydrocortisone, and blood contamination on salivary cortisol but not cortisone

Author

Marcus Imamovic, Nils Bäcklund, Staffan Lundstedt, Göran Brattsand, Elisabeth Aardal, Tommy Olsson, and Per Dahlqvist

Subjects
cushing’s syndrome, salivary cortisol, salivary cortisone, liquorice, sample contamination, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective: To determine the effects of liquorice consumption, topical hydro cortisone, and blood contamination on salivary cortisol and cortisone concentrations. Design and methods: Thirty healthy volunteers were randomized to a low, medium, or high dose of liquorice. Late-night saliva samples were colle cted using a Salivette® collection device at baseline, during 1 week of daily liquorice consumption, and during 4 weeks' washout. Saliva sampling was also performed before and after the application of topical hydrocortisone on the skin. Furthermore, in a subgroup (n = 16), saliva and venous blood were collected from each individual and mixed to achieve graded blood contamination in saliva. Salivary cortisol and cortisone were a nalyzed with liquid chromatography-tandem mass spectrometry. Results: Significant increases in salivary cortisol concentrations were o bserved during medium- (+49%) and high-dose (+97%) liquorice intake, which ret urned to baseline 4 days after liquorice withdrawal. Topical hydrocortisone on finge rs holding the collection swab increased salivary cortisol concentrations >1000-fold with concomitant pronounced elevation of the cortisol:cortisone ratio. Salivary cortisol in creased significantly after contamination with blood ≥0.5%. Visual examination could safely detect these samples. Salivary cortisone concentrations were unaffected by liquorice c onsumption and blood contamination, and only marginally affected by topical hydrocort isone. Conclusion: Liquorice, topical hydrocortisone, and blood contamination may all cause elevated salivary cortisol concentrations. Improved sampling instructions and visual examination of the sample may minimize these risks. Salivary cortisone is essentially unaffected by the different preanalytical confounders and may be used as a first-line screening test for Cushing's syndrome.

Published
2022
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3. Acromegaly management in the Scandinavian countries - a DELPHI consensus survey

Author

Mai C. Arlien-Soborg, Jakob Dal, Ansgar Heck, Kirstine Stochholm, Nielsen Eigil H, Claus Feltoft, Rasmussen AEse Krogh, Ulla Feldt-Rasmussen, Mikkel Andreassen, Marianne Klose, Nielsen Torben Leo, Marianne Andersen, Christensen Louise Lehmann, Jesper Krogh, Anne Jarlov, Fougner Stine Lyngvi, Ingrid Nermoen, Jens Bollerslev, Marianne Oksnes, Per Dahlqvist, Tommy Olsson, Katarina Berinder, Charlotte Hoybye, Maria Petersson, Anna-Karin AEkerman, Jeanette Wahlberg, Bertil Ekman, Engstrom Britt Eden, Gudmundur Johannsson, Oskar Ragnarsson, Sigurjonsdottir Helga Agusta, Pia Burman, and Jorgensen Jens Otto

Subjects
General Medicine
Published
2023
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4. Confounding effects of liquorice, hydrocortisone, and blood contamination on salivary cortisol but not cortisone

Author

Marcus Imamovic, Nils Bäcklund, Staffan Lundstedt, Göran Brattsand, Elisabeth Aardal, Tommy Olsson, and Per Dahlqvist

Subjects
Endocrinology, Cushing’s syndrome, Endocrinology, Diabetes and Metabolism, Endokrinologi och diabetes, Internal Medicine, liquorice, sample contamination, Endocrinology and Diabetes, salivary cortisone, salivary cortisol
Abstract

Objective To determine the effects of liquorice consumption, topical hydrocortisone, and blood contamination on salivary cortisol and cortisone concentrations. Design and methods Thirty healthy volunteers were randomized to a low, medium, or high dose of liquorice. Late-night saliva samples were collected using a Salivette® collection device at baseline, during 1 week of daily liquorice consumption, and during 4 weeks' washout. Saliva sampling was also performed before and after the application of topical hydrocortisone on the skin. Furthermore, in a subgroup (n = 16), saliva and venous blood were collected from each individual and mixed to achieve graded blood contamination in saliva. Salivary cortisol and cortisone were analyzed with liquid chromatography-tandem mass spectrometry. Results Significant increases in salivary cortisol concentrations were observed during medium- (+49%) and high-dose (+97%) liquorice intake, which returned to baseline 4 days after liquorice withdrawal. Topical hydrocortisone on fingers holding the collection swab increased salivary cortisol concentrations >1000-fold with concomitant pronounced elevation of the cortisol:cortisone ratio. Salivary cortisol increased significantly after contamination with blood ≥0.5%. Visual examination could safely detect these samples. Salivary cortisone concentrations were unaffected by liquorice consumption and blood contamination, and only marginally affected by topical hydrocortisone. Conclusion Liquorice, topical hydrocortisone, and blood contamination may all cause elevated salivary cortisol concentrations. Improved sampling instructions and visual examination of the sample may minimize these risks. Salivary cortisone is essentially unaffected by the different preanalytical confounders and may be used as a first-line screening test for Cushing's syndrome.

Published
2023
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8. Improved urinary cortisol metabolome in addison disease: A prospective trial of dual-release hydrocortisone

Author

Per Dahlqvist, Gudmundur Johannsson, Bertil Ekman, Ragnhildur Bergthorsdottir, Pia Burman, Oskar Ragnarsson, Johanna McQueen, Britt Edén Engström, Stephanie Espiard, Mark Sherlock, Stanko Skrtic, Jeanette Wahlberg, and Paul M. Stewart

Subjects
medicine.medical_specialty, medicine.drug_class, business.industry, Urinary system, Tetrahydrocortisol, Context (language use), Primary Adrenal Insufficiency, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, medicine, Metabolome, Corticosteroid, Tetrahydrocortisone, business, Hydrocortisone, medicine.drug
Abstract

CONTEXT: Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy has demonstrated an improved metabolic profile compared to conventional 3-times-daily (TID-HC) therapy among patients with primary adrenal insufficiency. This effect might be related to a more physiological cortisol profile, but also to a modified pattern of cortisol metabolism. OBJECTIVE: This work aimed to study cortisol metabolism during DR-HC and TID-HC. DESIGN: A randomized, 12-week, crossover study was conducted. INTERVENTION AND PARTICIPANTS: DC-HC and same daily dose of TID-HC were administered to patients with primary adrenal insufficiency (n = 50) vs healthy individuals (n = 124) as controls. MAIN OUTCOME MEASURES: Urinary corticosteroid metabolites were measured by gas chromatography/mass spectrometry at 24-hour urinary collections. RESULTS: Total cortisol metabolites decreased during DR-HC compared to TID-HC (P

Published
2021
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9. Biomarkers of cardiovascular disease and inflammation in autoimmune addison’s disease with residual adrenocortical function

Author

Bjorvatn Sævik Åse, Åkerman Anna-Karin, Paal Methlie, Marcus Quinkler, Jørgensen Anders, Höybye Charlotte, Aleksandra Debowska, Gunnar Nedrebø Bjørn, Anne Lise Dahle, Siri Carlsen, Aneta Tomkowicz, Holte Synnøve, Stina Therese Sollid, Ingrid Nermoen, Grønning Kaja, Per Dahlqvist, Guri Grimnes, Skov Jakob, Jakob Skov, Trine Finnes, Susanna Valland, Jeanette Wahlberg, Katerina Simunkova, Kämpe Olle, Eystein Sverre Husebye, Sophie Bensing, and Øksnes Marianne

Subjects
business.industry, Immunology, medicine, Inflammation, Disease, medicine.symptom, business, Function (biology)
Published
2021
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12. High usage of drugs for neuropsychiatric morbidity in patients with Cushing´s disease before diagnosis and at 5–10 years follow-up – a nationwide study

Author

Engstrom Britt Eden, Katarina Berinder, P Burman, Bertil Ekman, Oskar Ragnarsson, Charlotte Höybye, Daniel Bengtsson, Per Dahlqvist, and Jeanette Wahlberg

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine, In patient, Cushing's disease, business, medicine.disease
Published
2020
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13. Residual corticosteroid production in autoimmune addison´s disease

Author

Holte Synnøve Emblem, Sophie Bensing, Paal Methlie, Siri Carlsen, Katerina Simunkova, Aneta Tomkowicz, Guri Grimnes, Olle Kämpe, Ingrid Nermoen, Aleksandra Debowska, Jakob Skov, Anna-Karin Åkerman, Sollid Stina Therese, Per Dahlqvist, Charlotte Höybye, Kaja Grønning, Susanna Fonneland Valland, Marcus Quinkler, Trine Finnes, Marianne Øksnes, Saevik Åse Bjorvatn, Dahle Anne Lise, Jeanette Wahlberg, Jörgensen Anders Palmström, Nedrebo Bjorn Gunnar, and Husebye Eystein Sverre

Subjects
Autoimmune Addison's Disease, medicine.drug_class, business.industry, Immunology, medicine, Corticosteroid, business
Published
2020
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14. Residual adrenocortical function in autoimmune addison's disease: interim results of a cross-sectional study

Author

Jakob Skov, Marianne Øksnes, Siri Carlsen, Charlotte Höybye, Guri Grimnes, Eystein S. Husebye, Paal Methlie, Sophie Bensing, Per Dahlqvist, AEse Bjorvatn Saevik, Stina Therese Sollid, Synnove Emblem Holte, Magnus Isaksson, Nedrebo Bjorn Gunnar, Trine Finnes, Jeanette Wahlberg, Marcus Quinkler, Anna-Karin AEkermann, Aneta Tomkowicz, Anne Lise Dahle, Ingrid Nermone, Anders Palmstrøm Jørgensen, Aleksandra Debowska, and Kaja Grønning

Subjects
Pediatrics, medicine.medical_specialty, Autoimmune Addison's Disease, Cross-sectional study, business.industry, Interim, medicine, business
Published
2019
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15. DNA Methylation and fMRI responses in patients with Cushing's syndrome in remission - suggestions of a functional link between hypercortisolism and neurocognitive dysfunction

Author

Andreas Stomby, Johanna C. Andersson-Assarsson, Ragnhildur Bergthorsdottir, Oskar Ragnarsson, Per Dahlqvist, Gudmundur Johannsson, Lars Nyberg, and Camilla A M Glad

Subjects
Oncology, medicine.medical_specialty, S syndrome, Neurocognitive Dysfunction, business.industry, Internal medicine, DNA methylation, medicine, In patient, business
Published
2019
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16. Urinary steroid profile in patients with primary adrenal insufficiency under conventional glucocorticoid replacement: a case control study

Author

Per Dahlqvist, Engstrom Britt Eden, Anna Nilsson, Stephanie Espiard, Ragnhildur Bergthorsdottir, Oskar Ragnarsson, Bertil Ekman, Stanko Skrtic, Johanna McQueen, Mark Sherlock, Jeanette Wahlberg, Paul Stewart, Gudmundur Johannsson, and P Burman

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Urinary system, Case-control study, medicine, Urology, In patient, business, Glucocorticoid, Primary Adrenal Insufficiency, Steroid, medicine.drug
Published
2018
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18. The urinary cortisol metabolome in patients with adrenal insufficiency: dual-release hydrocortisone is less deleterious than conventional hydrocortisone therapy

Author

Stephanie Espiard, Bertil Ekman, Ragnhildur Bergthorsdottir, Stanko Skrtic, Mark Sherlock, Oskar Ragnarsson, Jeanette Wahlberg, Per Dahlqvist, Johanna McQueen, Anna Nilsson, Pia Burman, Britt Edén Engström, Paul Stewart, and Gudmundur Johannsson

Subjects
medicine.medical_specialty, Dual release, business.industry, Endocrinology, Diabetes and Metabolism, Urinary system, General Medicine, Metabolism, medicine.disease, Excretion, Endocrinology, Internal medicine, Adrenal insufficiency, Metabolome, Medicine, In patient, business, hormones, hormone substitutes, and hormone antagonists, Hydrocortisone, medicine.drug
Abstract

Introduction Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy provides a more physiological cortisol profile than conventional thrice-daily (TID) therapy and has demonstrated improved metabolic profile among patients with adrenal insufficiency (AI). The mechanisms by which this metabolic improvement occurs may be due to less total exposure, changed cortisol time exposure profile, but also modified metabolism of cortisol. Objective To study cortisol metabolism during DR-HC and TID. Methods Patients with primary AI received DR-HC or an equal total daily dose of TID in a crossover multi-center study. Cortisol metabolites were measured by gas chromatography/mass spectrometry on 24 h urinary collections after both treatments and in controls. Results Fifty patients (22 females, mean age 47 years) and 124 healthy controls (73 females, mean age 48 years) were included in the study. Total cortisol metabolites were significantly decreased during DR-HC [median: 6380 μg/24 h] compared to TID [8825 μg/24 h]; P Conclusion The urinary cortisol metabolome may be a more sensitive marker of “optimal cortisol replacement”. Abnormal cortisol metabolites excretion and cortisol metabolism are observed in patients receiving TID. This abnormal profile improves with DR-HC. Especially, reduced 11βHSD1 activity during DR-HC may mediate some of the beneficial metabolic effects previously observed with this treatment.

Published
2018
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19. Mortality is increased in patients with Cushing's disease in long-term remission: A nation-wide study

Author

Sophie Bensing, P Burman, Bertil Ekman, Eva Andersson, Oskar Ragnarsson, Eva Marie Erfurth, Per Dahlqvist, Elin Segerstedt, Erik Schwarcz, Eleni Papakokkinou, Tommy Olsson, Katarina Berinder, Jeanette Wahlberg, Daniel S Olsson, Charlotte Höybye, Britt Edén Engström, Dimitrios Chantzichristos, Ing-Liss Bryngelsson, Gudmundur Johannsson, and Cecilia Folin

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine, In patient, Long term remission, Cushing's disease, business, medicine.disease
Published
2017
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21. A Phase 3b, open-label, extension study to evaluate the long-term safety of once-daily, dual-release hydrocortisone (DR-HC) in patients with adrenal insufficiency (AI)

Author

Claudio Marelli, Anna Nilsson, Jeanette Wahlberg, Sharif Uddin, Engstrom Britt Eden, Ragnhildur Bergthorsdottir, Bertil Ekman, Oskar Ragnarsson, Gudmundur Johannsson, P Burman, Heinrich Achenbach, Per Dahlqvist, and Stanko Skrtic

Subjects
medicine.medical_specialty, Pediatrics, Dual release, business.industry, Extension study, medicine.disease, medicine, Adrenal insufficiency, In patient, Long term safety, Once daily, Open label, business, Intensive care medicine, Hydrocortisone, medicine.drug
Published
2016
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22. Sleep apnea in patients with acromegaly - prevalence, diagnosis and risk factors

Author

Karl A. Franklin, Helena Wik, Charlotte Höybye, Maria Warn, Maria Forsgren, Per Dahlqvist, Oskar Ragnarsson, Jenny Tiberg, Christina Dahlgren, P Burman, Britt Edén Engström, Anna-Karin AEkerman, Konstantina Vouzouneraki, Jeanette Wahlberg, Ann-Sofie Nilsson, and Caroline Alkebro

Subjects
Pediatrics, medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Acromegaly, medicine, Sleep apnea, In patient, medicine.disease, business
Published
2016
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