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Your search keyword '"Vincent Prevot"' showing total 7 results
Start Over Author "Vincent Prevot" Publisher bioscientifica
7 results on '"Vincent Prevot"'

1. Investigating intranasal kisspeptin as a novel, effective and preferable route of delivery using human, rodent and pharmaceutical models

Author

Edouard G Mills, Magda Swedrowska, Virginia Delli, Konstantina Chachlaki, Mauro Sergio, Laurine Decoster, Gaetan Ternier, Layla Thurston, Maria Phylactou, Bijal Patel, Lisa Yang, Sophie Clarke, Beatrice Muzi, Emma Alexander, Muhammad Choudhury, Paul Bech, Ali Abbara, Ben Forbes, Paolo Giacobini, Vincent Prevot, Alexander Comninos, and Waljit Dhillo

Subjects
General Medicine
Published
2023

2. GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

Author

Giuliana, Pellegrino, Marion, Martin, Cécile, Allet, Tori, Lhomme, Sarah, Geller, Delphine, Franssen, Virginie, Mansuy, Maria, Manfredi-Lozano, Adrian, Coutteau-Robles, Virginia, Delli, S, Rasika, Danièle, Mazur, Anne, Loyens, Manuel, Tena-Sempere, Juergen, Siepmann, François P, Pralong, Philippe, Ciofi, Gabriel, Corfas, Anne-Simone, Parent, Sergio R, Ojeda, Ariane, Sharif, and Vincent, Prevot

Subjects
Gonadotropin-Releasing Hormone, Neurons, Astrocytes, Hypothalamus, Sexual Maturation, General Economics, Econometrics and Finance
Abstract

Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Here, we show that rodent GnRH neurons use a prostaglandin D

Published
2022

3. The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

Author

Vincent Prevot, Michael D Culler, Éva Rumpler, András Matolcsy, Gábor Szabó, Csaba Vastagh, Erik Hrabovszky, Viktória Váczi, Miklós Sárvári, Szilárd Póliska, Cecile Allet, Imre Farkas, Gergely Rácz, Paolo Giacobini, Norbert Solymosi, Balázs Göcz, Szabolcs Takács, Katalin Skrapits, Ferenc Erdélyi, Blanka Tóth, and Ludovica Cotellessa

Subjects
0301 basic medicine, human transcriptomics, Male, striatum, Striatum, Gonadotropin-releasing hormone, Basal Ganglia, Gonadotropin-Releasing Hormone, 0302 clinical medicine, Basal ganglia, Biology (General), Cells, Cultured, Neurons, Basal forebrain, cholinergic interneurons, General Neuroscience, Putamen, General Medicine, Middle Aged, Choline acetyltransferase, Medicine, Female, General Economics, Econometrics and Finance, hormones, hormone substitutes, and hormone antagonists, Research Article, Human, Adult, Cell type, endocrine system, Basal Forebrain, QH301-705.5, Science, Transgene, RNA-sequencing, Biology, Medium spiny neuron, General Biochemistry, Genetics and Molecular Biology, Choline O-Acetyltransferase, 03 medical and health sciences, Humans, General Immunology and Microbiology, neuropeptides, Cell Biology, 030104 developmental biology, nervous system, GnRH, Cholinergic, Transcriptome, Neuroscience, 030217 neurology & neurosurgery
Abstract

Human reproduction is controlled by ∼2,000 hypothalamic gonadotropin-releasing hormone (GnRH) neurons. Here we report the discovery and characterization of additional 150-200,000 GnRH-synthesizing cells in the human basal ganglia and basal forebrain. Extrahypothalamic GnRH neurons were cholinergic. Though undetectable in adult rodents, the GnRH-GFP transgene was expressed transiently by caudate-putamen cholinergic interneurons in newborn transgenic mice. In slice electrophysiological studies, GnRH inhibited these interneurons via GnRHR1 autoreceptors. Whole-transcriptome analysis of cholinergic interneurons and medium spiny projection neurons laser-microdissected from the human putamen confirmed selective expression of GNRH1 and GNRHR1 autoreceptors in cholinergic cells and uncovered the detailed transcriptome profile and molecular connectome of these two cell types. Higher- order non-reproductive functions regulated by GnRH under physiological conditions in the human basal ganglia and basal forebrain require clarification. GnRH/GnRHR1 signaling as a potential therapeutic target in the treatment of neurodegenerative disorders affecting cholinergic neurocircuitries, including Parkinson’s and Alzheimer’s diseases, needs to be explored.

Published
2022

6. Defining reference ranges for serum anti-Mullerian hormone (AMH) on a large cohort of normozoospermic adult men highlights new potential physiological functions of AMH on FSH secretion and sperm motility

Author

Benderradji, Hamza, primary, Anne-Laure, Barbotin, additional, Maryse, Leroy-Billiard, additional, Julie, Prasivoravong, additional, Francois, Marcelli, additional, Christine, Decanter, additional, Geoffroy, Robin, additional, Valerie, Mitchell, additional, Jean-Marc, Rigot, additional, Antonino, Bongiovanni, additional, Florent, Sauve, additional, Luc, Buee, additional, Claude-Alain, Maurage, additional, Maryse, Cartigny, additional, Arnauld, Villers, additional, Vincent, Prevot, additional, Sophie, Catteau-Jonard, additional, Nicolas, Sergeant, additional, Paolo, Giacobini, additional, Pascal, Pigny, additional, and Clara, Leroy, additional

Published
2022
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