1. Indoxyl derivatives of drug metabolites.
- Author
-
Faigle JW, Stierlin H, Mory H, Winkler T, and Kriemler HP
- Subjects
- Animals, Anti-Anxiety Agents urine, Chemical Phenomena, Chemistry, Dogs, Magnetic Resonance Spectroscopy, Male, Mass Spectrometry, Rats, Benzodiazepines urine, Benzophenones urine, Indoles urine
- Abstract
Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.
- Published
- 1985
- Full Text
- View/download PDF