19 results on '"Hipler, Uta-Christina"'
Search Results
2. S1 Guideline onychomycosis.
- Author
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Nenoff P, Reinel D, Mayser P, Abeck D, Bezold G, Bosshard PP, Brasch J, Daeschlein G, Effendy I, Ginter-Hanselmayer G, Gräser Y, Hamm G, Hengge U, Hipler UC, Höger P, Kargl A, Kolb-Mäurer A, Krüger C, Malisiewicz B, Mayer J, Ott H, Paasch U, Schaller M, Uhrlaß S, and Zidane M
- Subjects
- Adolescent, Humans, Child, Antifungal Agents therapeutic use, Nails, Administration, Oral, Europe, Onychomycosis diagnosis, Onychomycosis drug therapy
- Abstract
Onychomycosis is a fungal infection of the fingernails and toenails. In Europe, tinea unguium is mainly caused by dermatophytes. The diagnostic workup comprises microscopic examination, culture and/or molecular testing (nail scrapings). Local treatment with antifungal nail polish is recommended for mild or moderate nail infections. In case of moderate to severe onychomycosis, oral treatment is recommended (in the absence of contraindications). Treatment should consist of topical and systemic agents. The aim of this update of the German S1 guideline is to simplify the selection and implementation of appropriate diagnostics and treatment. The guideline was based on current international guidelines and the results of a literature review conducted by the experts of the guideline committee. This multidisciplinary committee consisted of representatives from the German Society of Dermatology (DDG), the German-Speaking Mycological Society (DMykG), the Association of German Dermatologists (BVDD), the German Society for Hygiene and Microbiology (DGHM), the German Society of Pediatric and Adolescent Medicine (DGKJ), the Working Group for Pediatric Dermatology (APD) and the German Society for Pediatric Infectious Diseases (DGPI). The Division of Evidence-based Medicine (dEBM) provided methodological assistance. The guideline was approved by the participating medical societies following a comprehensive internal and external review., (© 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.)
- Published
- 2023
- Full Text
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3. Dermatophyte infections in children compared to adults in Germany: a retrospective multicenter study in Germany.
- Author
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Kromer C, Celis D, Hipler UC, Zampeli VA, Mößner R, and Lippert U
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- Adult, Child, Germany epidemiology, Hand Dermatoses, Humans, Microsporum, Retrospective Studies, Tinea, Trichophyton, Arthrodermataceae, Dermatomycoses diagnosis, Dermatomycoses epidemiology
- Abstract
Background and Objective: Dermatophyte infections of the skin and nails are common worldwide and vary between geographical areas and over time. The aim of this study was to determine the epidemiological profile of dermatophytes in Germany with a focus on comparing children with adults., Patients and Methods: In this retrospective multicenter study, mycological dermatophyte culture results in the period 01/2014 to 12/2016 were analyzed according to identified pathogen, age and gender of patients, and type of disease., Results: Of 1,136 infections (children: n = 88, adults: n = 1,048), 50.8 % were clinically classified as onychomycosis, followed by tinea pedis (34.6 %), tinea corporis (16.2 %), tinea manus (16.2 %), tinea capitis (2.5 %), and tinea faciei (1.2 %). The most frequent pathogen was Trichophyton (T.) rubrum (78.6 %), followed by T. interdigitale (14.3 %), T. benhamiae (3.2 %), T. mentagrophytes (2.1 %), and Microsporum canis (1.7 %). The fungal spectrum differed particularly in tinea corporis and tinea capitis between children and adults with a more diverse pathogen spectrum in children. Trichophyton tonsurans was rarely identified as cause for tinea corporis (2.7 %) or tinea capitis (3.3 %)., Conclusions: Differences in pathogens and frequency of fungal infections between age groups should be considered for optimal selection of the appropriate therapeutic regimen., (© 2021 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.)
- Published
- 2021
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4. Dermatophyten-Infektionen bei Kindern und Erwachsenen in Deutschland - eine retrospektive multizentrische Studie.
- Author
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Kromer C, Celis D, Hipler UC, Zampeli VA, Mößner R, and Lippert U
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- 2021
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- View/download PDF
5. S1-Leitlinie Tinea capitis.
- Author
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Mayser P, Nenoff P, Reinel D, Abeck D, Brasch J, Daeschlein G, Effendy I, Ginter-Hanselmayer G, Gräser Y, Hipler UC, Höger P, Kolb-Mäurer A, Ott H, Schaller M, and Zidane M
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- 2020
- Full Text
- View/download PDF
6. S1 guidelines: Tinea capitis.
- Author
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Mayser P, Nenoff P, Reinel D, Abeck D, Brasch J, Daeschlein G, Effendy I, Ginter-Hanselmayer G, Gräser Y, Hipler UC, Höger P, Kolb-Mäurer A, Ott H, Schaller M, and Zidane M
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- Adult, Child, Hair microbiology, Humans, Scalp microbiology, Trichophyton, Antifungal Agents therapeutic use, Tinea Capitis diagnosis, Tinea Capitis drug therapy
- Abstract
Tinea capitis describes a dermatophyte infection of scalp and hair that predominately occurs in children. The diagnostic workup includes microscopic examination, culture and/or molecular tests. Treatment is guided by the specific organism involved and should consist of systemic agents as well as adjuvant topical treatment. The aim of the present update of the interdisciplinary German S1 guidelines is to provide dermatologists, pediatricians and general practitioners with a decision tool for selecting and implementing appropriate diagnostic and therapeutic measures in patients with tinea capitis. The guidelines were developed based on current international guidelines, in particular the 2010 European Society for Pediatric Dermatology guidelines and the 2014 British Association of Dermatologists guidelines, as well as on a review of the literature conducted by the guideline committee. This multidisciplinary committee consists of representatives from the German Society of Dermatology (DDG), the German-Speaking Mycological Society (DMykG), the German Society for Hygiene and Microbiology (DGHM), the German Society of Pediatric and Adolescent Medicine (DGKJ) and the German Society for Pediatric Infectious Diseases (DGPI). The Division of Evidence-based Medicine (dEBM) provided methodological assistance. The guidelines were approved by the participating medical societies following a comprehensive internal and external review., (© 2020 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.)
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- 2020
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7. Schmerzhafte umschriebene bullöse Dermatose an der linken Hand nach Kontakt zu afrikanischen Weißbauchigeln.
- Author
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Gebauer S, Uhrlaß S, Koch D, Krüger C, Rahmig N, Hipler UC, and Nenoff P
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- 2018
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8. Painful circumscribed bullous dermatosis of the left hand after contact with African four-toed hedgehogs.
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Gebauer S, Uhrlass S, Koch D, Krüger C, Rahmig N, Hipler UC, and Nenoff P
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- Adult, Animals, Female, Humans, Skin Diseases, Vesiculobullous therapy, Tinea therapy, Hedgehogs, Skin Diseases, Vesiculobullous etiology, Skin Diseases, Vesiculobullous pathology, Tinea etiology, Tinea pathology
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- 2018
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9. Primary cutaneous aspergillosis - an uncommon opportunistic infection Review of the literature and case presentation.
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Darr-Foit S, Schliemann S, Scholl S, Hipler UC, and Elsner P
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- Aged, Aspergillosis microbiology, Dermatomycoses microbiology, Female, Humans, Scalp Dermatoses microbiology, Skin microbiology, Aspergillosis diagnosis, Aspergillus fumigatus isolation & purification, Dermatomycoses diagnosis, Leukemia, Lymphocytic, Chronic, B-Cell complications, Opportunistic Infections, Scalp Dermatoses diagnosis, Skin pathology
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- 2017
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10. Primär kutane Aspergillose - eine seltene opportunistische Infektion Ein Fallbericht mit Literaturübersicht.
- Author
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Darr-Foit S, Schliemann S, Scholl S, Hipler UC, and Elsner P
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- 2017
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11. Diagnostic precision of component-resolved vs. extract-based in vitro diagnosis of hymenoptera venom allergy: effects on clinical management.
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Seyfarth F, Miguel D, Schliemann S, and Hipler UC
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- Allergens immunology, Humans, Immunoassay methods, Male, Reproducibility of Results, Sensitivity and Specificity, Specimen Handling methods, Bee Venoms immunology, Hypersensitivity diagnosis, Hypersensitivity immunology, Immunoglobulin E immunology, Insect Bites and Stings diagnosis, Insect Bites and Stings immunology, Skin Tests methods
- Abstract
Background: The measurement of specific IgE (sIgE) antibodies plays a key role in the diagnosis of honeybee and wasp venom allergy. In recent years, component-resolved diagnosis (CRD) has been introduced, which allows for the measurement of sIgE antibodies against Api m 1, Ves v 1, Ves v 5, and Pol d 5, as well as cross-reactive carbohydrate determinants (CCDs). These tests are intended to help determine the clinical relevance of any given sensitization, especially in patients with dual sensitization., Patients and Methods: Specific IgE antibody levels were measured in 143 patients with bee and/or wasp venom allergy using the extract-based ImmunoCAP
® allergens i1 and i3 as well as the ImmunoCAP® allergen components i208-211 and O214 (Api m 1, Ves v 1, Ves v 5, Pol d 5, CCDs). In patients with dual sensitization, inhibition testing was also performed. In a subgroup of the study population, sIgE to Api m 1, Api m 4, Pol d 5, and Ves v 5 were determined using the ISAC® allergy microarray (n = 44)., Results: The sensitivity of Ves v 5 in patients with isolated wasp venom allergy was 78.5 %; in combination with Ves v 1, that figure increased to 92.3 %. The sensitivity of Api m 1 in individuals with isolated bee venom allergy was 25 %. CRD and inhibition testing in individuals with dual sensitization showed divergent results. CRD using the ISAC® allergy microarray showed marked differences, especially with regard to Api m 1 and CCDs., Conclusion: Component-resolved tests are a valuable addition to the diagnostic spectrum as long as they are used in combination with established procedures. Apart from Ves v 5, measuring IgE antibodies to Ves v 1 should always be included in the diagnostic workup., (© 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)- Published
- 2017
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12. Diagnostische Präzision der komponentenbasierten vs. der extraktbasierten In-vitro-Diagnostik von Insektengift-Allergien: Auswirkungen auf das klinische Management.
- Author
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Seyfarth F, Miguel D, Schliemann S, and Hipler UC
- Abstract
Hintergrund: Die Bestimmung von spezifischen IgE-Antikörpern spielt eine zentrale Bedeutung bei der Diagnostik von Bienen- und Wespengiftallergien. In den letzten Jahren wurden die komponentenbasierte Diagnostik (CRD) eingeführt, die die Bestimmung spezifischer IgE-Antikörper gegen die Allergene Api m 1, Ves v 1, Ves v 5 und Pol d 5 sowie kreuzreaktive Kohlenhydratdeterminanten (CCDs) erlaubt. Hierdurch soll vor allem bei Probanden mit Doppelsensibilisierungen die klinische Relevanz der einzelnen Sensibilisierungen besser beurteilt werden können., Probanden Und Methodik: Die spezifischen IgE-Antikörper-Bestimmungen an 143 Probanden mit Bienen- und/oder Wespengiftallergie erfolgten mit den extraktbasierten ImmunoCAP®-Allergenen i1 und i3 sowie den ImmunoCAP®-Allergenkomponenten i208-211 und o214 (Api m 1, Ves v 1, Ves v 5, Pol d 5, CCD). Bei Doppelsensibilisierten wurde zusätzlich ein Inhibitionstest durchgeführt. An einem Teilkollektiv der Studienpopulation erfolgten sIgE-Bestimmungen gegen Api m 1, Api m 4, Pol d 5 und Ves v 5 mittels Allergiechip (ISAC®, n = 44)., Ergebnisse: Die Sensitivität von Ves v 5 bei isolierten Wespengiftallergikern betrug 78,5 %, gemeinsam mit Ves v 1 stieg diese auf 92,3 %. Die Sensitivität von Api m 1 bei isolierten Bienengiftallergikern betrug 25 %. Die komponentenbasierte Diagnostik und Inhibitionstests bei Doppelsensibilisierten lieferten divergente Ergebnisse. Die CRD mittels ISAC®-Allergiechip erbrachte deutliche Unterschiede vor allem im Hinblick auf die Diagnostik von Api m 1 und CCDs., Schlussfolgerungen: Die CRD bereichert das diagnostische Spektrum, sofern sie nicht allein sondern zusätzlich zu den etablierten Verfahren eingesetzt wird. Sie sollte neben Ves v 5 stets die Bestimmung der IgE-Antikörper gegen Ves v 1 umfassen., (© 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)
- Published
- 2017
- Full Text
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13. Are the classic diagnostic methods in mycology still state of the art?
- Author
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Wiegand C, Bauer A, Brasch J, Nenoff P, Schaller M, Mayser P, Hipler UC, and Elsner P
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- Dermatology, Fungi, Humans, Polymerase Chain Reaction, Dermatomycoses diagnosis, Mycology
- Abstract
The diagnostic workup of cutaneous fungal infections is traditionally based on microscopic KOH preparations as well as culturing of the causative organism from sample material. Another possible option is the detection of fungal elements by dermatohistology. If performed correctly, these methods are generally suitable for the diagnosis of mycoses. However, the advent of personalized medicine and the tasks arising therefrom require new procedures marked by simplicity, specificity, and swiftness. The additional use of DNA-based molecular techniques further enhances sensitivity and diagnostic specificity, and reduces the diagnostic interval to 24-48 hours, compared to weeks required for conventional mycological methods. Given the steady evolution in the field of personalized medicine, simple analytical PCR-based systems are conceivable, which allow for instant diagnosis of dermatophytes in the dermatology office (point-of-care tests)., (© 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)
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- 2016
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14. Sind die klassischen Methoden zur mykologischen Diagnostik noch "State-of-the-Art"?
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Wiegand C, Bauer A, Brasch J, Nenoff P, Schaller M, Mayser P, Hipler UC, and Elsner P
- Abstract
Die Labordiagnose einer Pilzinfektion der Haut basiert traditionell auf dem Nativpräparat und der Anzucht des Erregers aus dem klinischen Material. Auch der dermato- histologischer Nachweis von Pilzelementen ist möglich. Diese Methoden sind, sofern sie korrekt ausgeführt werden, in der Regel zum Pilznachweis geeignet. Im Zuge der personalisierten Medizin und den daraus erwachsenden Aufgaben werden jedoch neue Verfahren erforderlich, welche einfach, spezifisch und schnell sind. Der zusätzliche Einsatz von DNA-basierten molekularen Methoden erhöht die Empfindlichkeit sowie die diagnostische Spezifität und reduziert die zum Teil wochenlange Durchführungszeit der konventionellen mykologischen Diagnostik auf 24 bis 48 Stunden. Im Zuge der stetigen Weiterentwicklung im Bereich der personalisierten Medizin sind einfache Analysensysteme auf PCR-Basis denkbar, die in der Hautarztpraxis eine Dermatophyten-Sofort-Diagnostik erlauben (Point-of-Care-Tests)., (© 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)
- Published
- 2016
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15. Trichophyton species of Arthroderma benhamiae - a new infectious agent in dermatology.
- Author
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Nenoff P, Uhrlaß S, Krüger C, Erhard M, Hipler UC, Seyfarth F, Herrmann J, Wetzig T, Schroedl W, and Gräser Y
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- Animals, Dermatomycoses microbiology, Humans, Tinea microbiology, Antifungal Agents therapeutic use, Dermatomycoses diagnosis, Dermatomycoses drug therapy, Guinea Pigs microbiology, Tinea diagnosis, Tinea drug therapy, Trichophyton
- Abstract
In Germany, infections due to the zoophilic dermatophyte Trichophyton (T.) species of Arthroderma benhamiae are being more frequently diagnosed. The source of infection of this emerging pathogen overlaps with that of the zoophilic species T. interdigitale. The most common source are guinea pigs. T. species of Arthroderma benhamiae causes inflammatory dermatophytosis in children and adolescents. In addition to tinea capitis, it may cause both tinea corporis, tinea manus and frequently tinea faciei. In Germany, T. species of Arthroderma benhamiae is a frequent zoophilic dermatophyte, which in regions is probably more frequent than Microsporum canis. The mycological identification of the isolates with their yellow stained colonies is based on their macroscopic and microscopic features. However, some exhibit colony features consistent with those of T. interdigitale. These strains only can be identified unambiguously by means of molecular techniques. Using detection methods such as PCR-ELISA or real-time PCR, the dermatophyte can be identified directly from clinical material. Sequencing of the internal transcribed spacer region (ITS) of the ribosomal DNA has been approved as culture confirmation test for T. species of Arthroderma benhamiae. In addition, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) is useful. Widespread dermatophytosis due to T. species of Arthroderma benhamiae, in particular of tinea capitis, requires oral antifungal agents. Terbinafine is most effective, alternatives are fluconazole and itraconazole., (© 2014 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)
- Published
- 2014
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16. Tinea of glabrous skin.
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Seebacher C, Korting HC, Abeck D, Brasch J, Cornely O, Effendy I, Ginter-Hanselmayer G, Haake N, Hamm G, Hipler UC, Hof H, Mayser P, Ruhnke M, Schlacke KH, and Tietz HJ
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- Humans, Tinea microbiology, Tinea diagnosis, Tinea therapy
- Published
- 2010
- Full Text
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17. [Oral candidiasis].
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Reinel D, Plettenberg A, Seebacher C, Abeck D, Brasch J, Cornely O, Effendy I, Ginter-Hanselmayer G, Haake N, Hamm G, Hipler UC, Hof H, Korting HC, Mayser P, Ruhnke M, Schlacke KH, and Tietz HJ
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- Administration, Oral, Administration, Topical, Adult, Antifungal Agents therapeutic use, Candidiasis, Oral drug therapy, Candidiasis, Oral etiology, Child, Diagnosis, Differential, Dose-Response Relationship, Drug, Drug Administration Schedule, Humans, Infant, Infant, Newborn, Microbiological Techniques, Opportunistic Infections diagnosis, Candidiasis, Oral diagnosis, Evidence-Based Medicine
- Published
- 2008
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18. Onychomycosis.
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Seebacher C, Brasch J, Abeck D, Cornely O, Effendy I, Ginter-Hanselmayer G, Haake N, Hamm G, Hipler UC, Hof H, Korting HC, Mayser P, Ruhnke M, Schlacke KH, and Tietz HJ
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- Humans, Antifungal Agents therapeutic use, Dermatologic Agents therapeutic use, Dermatology standards, Onychomycosis diagnosis, Onychomycosis drug therapy, Practice Guidelines as Topic, Practice Patterns, Physicians' standards
- Published
- 2007
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19. Tinea capitis.
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Seebacher C, Abeck D, Brasch J, Cornely O, Daeschlein G, Effendy I, Ginter-Hanselmayer G, Haake N, Hamm G, Hipler UC, Hof H, Korting HC, Kramer A, Mayser P, Ruhnke M, Schlacke KH, and Tietz HJ
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- Administration, Oral, Adult, Anti-Infective Agents, Local administration & dosage, Anti-Infective Agents, Local therapeutic use, Antifungal Agents administration & dosage, Antifungal Agents therapeutic use, Child, Diagnosis, Differential, Double-Blind Method, Griseofulvin administration & dosage, Griseofulvin therapeutic use, Humans, Itraconazole administration & dosage, Itraconazole therapeutic use, Naphthalenes administration & dosage, Naphthalenes therapeutic use, Povidone-Iodine administration & dosage, Povidone-Iodine therapeutic use, Practice Guidelines as Topic, Randomized Controlled Trials as Topic, Soaps, Terbinafine, Time Factors, Treatment Outcome, Tinea Capitis diagnosis, Tinea Capitis drug therapy, Tinea Capitis prevention & control, Tinea Capitis transmission
- Published
- 2006
- Full Text
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