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Histologic grade is an important prognostic factor for both local recurrence and metastatic potential with canine soft tissue sarcoma (STS). Pre-treatment biopsy with identification of tumour grade may aid in prognostication and determination of surgical margins necessary for local control. The purpose of this study was to evaluate the grading accuracy of various pre-treatment biopsy techniques (wedge, punch, needle-core) for STS in dogs. Medical records of 68 dogs diagnosed with a STS via pre-treatment biopsy and confirmed by excisional biopsy were evaluated. The concordance in grade between excisional and pre-treatment biopsies was 59%. Of the 41% that lacked concordance, 29% of pre-treatment biopsies underestimated and 12% overestimated grade. The method of pre-treatment biopsy did not significantly effect grade concordance. Based on these data, needle-core biopsy appears to be similar in accuracy compared to open biopsy, however, grading determined by pre-treatment biopsy in general should be interpreted with caution., (© 2012 John Wiley & Sons Ltd.)

Overexpression of the chemokine monocyte chemotactic protein-1 (MCP-1) has been associated with a poor prognosis in many human cancers. Increased MCP-1 concentrations may promote tumour progression by increasing mobilization of myeloid derived suppressor cells such as immature monocytes and neutrophils. We hypothesized that increased numbers of peripheral neutrophils or monocytes and increased MCP-1 concentrations would predict a worse outcome in dogs with multicentric lymphoma. In this retrospective study involving 26 client-owned dogs diagnosed with lymphoma, we show that peripheral neutrophil and monocyte counts as well as serum MCP-1 concentrations were significantly elevated relative to healthy control animals, and that such increases were associated with a decreased disease-free interval in dogs treated with chemotherapy based on cyclophosphamide, vincristine, doxorubicin and prednisone (CHOP). To our knowledge, this is the first study showing that pretreatment evaluation of monocyte and neutrophil counts can provide important prognostic information in dogs with lymphoma. The mechanisms underlying these observations remain to be determined., (© 2010 Blackwell Publishing Ltd.)

The Basic Character Inventory (BCI) contains 136 items, 17 lower-order personality factors and three higher-order personality factors derived from psychoanalytic theory: Oral, Obsessive Compulsion, and Hysteria. Previous research that investigated the BCI's psychometric properties examined small, special populations and did not use modern statistical methods to validate the BCI. The present study validates the BCI via confirmatory factor analyses using a large sample of 6,285 Norwegian nursing and teaching students. Reliability, convergent validity, and divergent validity of the BCI were also assessed. Results indicated general support for the original BCI factor structure in a reduced form of the BCI that possesses strong reliability and validity, and is suitable for use in time-limited measurement settings.

Although global self-esteem has historically been assumed to be a unidimensional construct, recent theory and research has challenged this assumption. Instead, it has been suggested that self-esteem might more fruitfully be viewed as a two-dimensional construct composed of: (a) self-liking, based on our perceptions of feedback from our social environment; and (b) self-competence, based on our internal conceptions of success and failure in performing tasks. The Self-Liking and Competence Scale (SLCS) is a self-esteem measure that has recently been developed based on this two-dimensional conceptualization of self-esteem. The purpose of the present research was to validate a Norwegian translation of the SLCS. 372 participants were given a translated version of the SLCS, and the translated scale exhibited psychometric properties similar to those of the original English version of the scale.

Seasonal deviations in normal eating habits have been associated with seasonal affective disorder (SAD) and bulimia nervosa (BN). Two studies on seasonal variation in eating habits are reported in this paper. In Study 1, seasonal patterns of eating disturbances were measured cross-sectionally in 6313 participants using an eating disturbance scale (EDS-5) and a modified version of the Seasonal Pattern Assessment Questionnaire (SPAQ). Eating disturbance scores were predicted by seasonal sensitivity scores from the SPAQ, gender, age, and light. Study 2 used a longitudinal design in which 908 participants were given the EDS-5 every month from November 1993 to January 1995. Scores on the EDS-5 fluctuated with the season of the year, with higher EDS-5 scores in winter and lower in summer. The results suggest that seasonal fluctuations affect only a subset of the total population.