1. Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors
- Author
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Moore, R.D., Rachlis, A.R., Silverberg, M.J., Muzaale, A.D., Locke, J.E., Eron, J.J., Gill, M.J., Mayor, A.M., Durand, C.M., Bosch, R.J., Boswell, S.L., Kitahata, M.M., Drozd, D.R., Martin, J.N., Massie, A.B., Napravnik, S., Butt, A.A., Fischer, M.J., Segev, D.L., Justice, A.C., Abraham, A.G., Kucirka, L.M., Lucas, G.M., Sperati, C.J., Horberg, M.A., and Althoff, K.N.
- Subjects
3. Good health - Abstract
New federal regulations allow HIV-positive individuals to be live kidney donors; however, potential candidacy for donation is poorly understood given the increased risk of end-stage renal disease (ESRD) associated with HIV infection. To better understand this risk, we compared the incidence of ESRD among 41 968 HIV-positive participants of North America AIDS Cohort Collaboration on Research and Design followed for a median of 5 years with the incidence of ESRD among comparable HIV-negative participants of National Health and Nutrition Examination III followed for a median of 14 years. We used risk associations from multivariable Cox proportional hazards regression to derive cumulative incidence estimates for selected HIV-positive scenarios (no history of diabetes, hypertension, AIDS, or hepatitis C virus coinfection) and compared these estimates with those from similarly selected HIV-negative scenarios. For 40-year-old HIV-positive individuals with health characteristics that were similar to those of age-matched kidney donors, viral load