1. Effect of peroxisome proliferator-activated receptor-alpha agonist (bezafibrate) on gastric secretion and gastric cytoprotection in rats.
- Author
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Pathak R, Asad M, Hrishikeshavan HJ, and Prasad S
- Subjects
- Acetic Acid, Animals, Ethanol, Gastric Acid metabolism, Gastric Mucosa drug effects, Gastric Mucosa metabolism, Gastric Mucosa pathology, Indomethacin, Male, Mucus metabolism, Rats, Rats, Wistar, Reperfusion Injury, Stomach Ulcer chemically induced, Stomach Ulcer metabolism, Stomach Ulcer pathology, Anti-Ulcer Agents pharmacology, Bezafibrate pharmacology, PPAR alpha agonists, Stomach Ulcer drug therapy
- Abstract
The effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) on gastric secretion and gastric cytoprotection was evaluated using five different models of gastric ulcers: acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol-induced, indomethacin-induced and ischemia-reperfusion-induced gastric ulcers. Bezafibrate, a PPAR-alpha agonist was administered at two different doses of 10 and 100 mg/kg body weight intraperitoneanally. Both doses of bezafibrate showed significant antiulcer effect in ethanol-induced, indomethacin-induced and pylorus ligation-induced gastric ulcers. Bezafibrate increased healing of ulcer in acetic acid-induced chronic gastric ulcer model. Both doses were also effective in preventing gastric lesions induced by ischemia-reperfusion. It was concluded that PPAR-alpha activation increases healing of gastric ulcers and also prevents development of gastric ulcers in rats.
- Published
- 2007
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