6 results on '"Mozos, Elena"'
Search Results
2. Clinical and histological findings of cutaneous wound healing in the red-eared slider turtle (Trachemys scripta elegans) housed in unheated outdoor enclosures.
- Author
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Negrini J, Ginel PJ, Novales M, Guerra R, and Mozos E
- Subjects
- Animals, Female, Wounds and Injuries pathology, Skin pathology, Turtles, Wound Healing physiology, Wounds and Injuries veterinary
- Abstract
Background: Cutaneous wounds are common in chelonians. The clinical and histological features of wound healing in these species are not well described and this prevents evaluation of new therapies., Objectives: To describe clinical and histopathological features of cutaneous wound healing in the red-eared slider turtle (Trachemys scripta elegans)., Animals: Twenty four healthy adult females housed in outdoor facilities with free access to water and exposed to daily variations in temperature., Methods: Full thickness 6 mm skin biopsy punch wounds were created in the rear limbs. The turtles were assigned to Group 1 (n = 12 for clinical evaluation) and Group 2 (n = 12 for microscopic study). Group 1 was photographed on Day 1 and weekly, until 28 days post wounding. Wound retraction was expressed as the percentage of perimeter reduction. For Group 2, three skin wounds were sampled at 2, 7, 14, 21, 28, 42, 60 and 135 days post wounding for histological study. The avidin-biotin-peroxidase (ABC) staining method was used to evaluate five commercial antibodies., Results: Wound contraction was limited; crust persisted at least 28 days. Re-epithelialization was complete by Day 14 in many animals; active inflammation persisted until 28 days; connective tissue re-constitution and remodelling was achieved from 42 to 135 days. Antibodies AE1/AE3, Factor VIII, MAC 387, CD3 and NCL-MSA showed cross reactivity with the cell counterpart in turtle tissues., Conclusions and Clinical Importance: Second intention wound healing progressed slowly and with an indolent behaviour. Microscopically there was marked overlapping of the inflammatory and proliferative phases over a long time period., (© 2016 ESVD and ACVD.)
- Published
- 2016
- Full Text
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3. Alopecia areata universalis in a dog.
- Author
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Ginel PJ, Blanco B, Pérez-Aranda M, Zafra R, and Mozos E
- Subjects
- Alopecia Areata diagnosis, Alopecia Areata drug therapy, Alopecia Areata pathology, Animals, Biopsy veterinary, Cyclosporine therapeutic use, Dog Diseases drug therapy, Dog Diseases pathology, Dogs, Immunosuppressive Agents therapeutic use, Male, Skin pathology, Alopecia Areata veterinary, Dog Diseases diagnosis
- Abstract
Background: Alopecia areata is a T-cell mediated autoimmune disease that occurs in humans and various other mammalian species. When the disease progresses to total alopecia it is defined as alopecia areata universalis (AAU), although this outcome has only been described in humans., Hypothesis/objectives: To describe a case of canine alopecia areata universalis and its clinical outcome after 22 months of follow-up., Animal: A 9-year-old intact male cross-breed hunting dog was presented with generalized and complete noninflammatory alopecia of 12-14 months duration., Methods: Clinical examination; histopathological and immunohistochemical examination of skin biopsies., Results: There was loss of all body hair including eyelashes and vibrissae. The histopathological and immunohistochemical findings supported a diagnosis of long-standing alopecia areata. Treatment with oral ciclosporin was associated with hair regrowth but muzzle hair, most eyelashes and whiskers were still lacking after 17 months of therapy., Conclusions and Clinical Importance: To the best of the author's knowledge this is the first documented case of canine AAU. The clinical and histopathological features were consistent with a diagnosis of AAU as defined in humans. Treatment with oral ciclosporin resulted in near complete resolution of the alopecia, but after 5 months without treatment the alopecia did not relapse and spontaneous resolution cannot be ruled out., (© 2015 ESVD and ACVD.)
- Published
- 2015
- Full Text
- View/download PDF
4. Allergen-specific immunotherapy in horses with insect bite hypersensitivity: a double-blind, randomized, placebo-controlled study.
- Author
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Ginel PJ, Hernández E, Lucena R, Blanco B, Novales M, and Mozos E
- Subjects
- Animals, Desensitization, Immunologic methods, Double-Blind Method, Enzyme-Linked Immunosorbent Assay veterinary, Female, Horse Diseases therapy, Horses, Immunoglobulin E, Insect Bites and Stings immunology, Male, Pruritus immunology, Pruritus veterinary, Allergens immunology, Ceratopogonidae immunology, Desensitization, Immunologic veterinary, Horse Diseases immunology, Hypersensitivity veterinary, Insect Bites and Stings veterinary
- Abstract
Background: Insect bite hypersensitivity (IBH) is a common cause of pruritus in horses, but there are few controlled studies on the efficacy of allergen-specific immunotherapy (ASIT). Atopic dermatitis and IBH can present with overlapping clinical signs; multiple insect and environmental allergens could be indicated in these horses to achieve effective hyposensitization. Although the success of ASIT using Culicoides spp. whole-body extracts is controversial, there are no controlled studies published that clearly show benefit from this form of therapy., Hypothesis/objectives: The objective was to evaluate the efficacy of ASIT in horses with IBH using commercially available extracts and tests., Animals: Twenty horses with seasonal pruritus and positive intradermal reactions to a whole Culicoides extract., Methods: An enzyme-linked immunosorbent assay test (Allercept(®) ) was used to detect concurrent allergen-specific IgE for other insects and environmental allergens. The ASIT was formulated by adding the relevant serologically positive allergens to the Culicoides extract. After randomization, 10 horses received ASIT and the rest a placebo solution. Clinical response was assessed every 4 months during 1 year using a clinical scoring system based on the severity of four clinical signs at 10 different body regions. Horses were not stabled and, to minimize dropouts, an insect repellent was used weekly in both groups., Results: Differences in clinical scores between groups were nonsignificant at any re-evaluation, while both groups improved to a similar extent, probably due to the insecticide treatment., Conclusions and Clinical Importance: Using commercially available extracts and tests, we could not demonstrate a beneficial effect of 1 year multiple ASIT in nonstabled horses with IBH., (© 2013 ESVD and ACVD.)
- Published
- 2014
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5. Comparison of three monoclonal and three polyclonal antibodies in the immunohistochemical diagnosis of canine autoimmune skin diseases.
- Author
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Pérez J, Arce C, Moreno A, Mozos E, Rodríguez F, and Llanes D
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- Animals, Autoimmune Diseases diagnosis, Case-Control Studies, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact veterinary, Dog Diseases immunology, Dogs, Immunohistochemistry veterinary, Lupus Erythematosus, Discoid diagnosis, Lupus Erythematosus, Discoid veterinary, Pemphigus diagnosis, Pemphigus veterinary, Predictive Value of Tests, Pyoderma diagnosis, Pyoderma veterinary, Sensitivity and Specificity, Skin Diseases diagnosis, Antibodies, Monoclonal, Autoantibodies immunology, Autoimmune Diseases veterinary, Dog Diseases diagnosis, Skin Diseases veterinary
- Abstract
The aim of this study was to evaluate the utility of three monoclonal antibodies (mAbs), and two anticanine IgG and one anticanine IgM polyclonal antibodies (pAbs) for the immunohistochemical diagnosis of canine autoimmune skin diseases. Skin biopsies from 11 cases of pemphigus (7 foliaceus, 3 vulgaris and 1 erythematosus), 12 cases of discoid lupus erythematosus (DLE) and 12 cases of chronic hyperplasic dermatitis were used. The CA4E7 mAb (IgG1 + IgG2) showed similar sensitivity, but higher specificity and lower background than the two anti-IgG pAbs for the immunohistochemical diagnosis of pemphigus and DLE. The CA4F1 mAb (IgG2) and CA3H1 mAb (IgG2) showed moderate and low interepithelial reactivity, respectively, in autoimmune skin diseases, but strong staining of the cytoplasm of plasma cells of the inflammatory infiltrates. These results suggest that the CA4E7 mAb may be valuable in the immunohistochemical diagnosis of such disorders.
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- 2002
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6. A Clinical, Pathological and I mmunopathological Study of Vitiligo in a Siamese Cat.
- Author
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López R, Ginel PJ, Molleda JM, Bautista MJ, Pérez J, and Mozos E
- Abstract
Abstract- The clinical, histopathological and ultrastructural features of a spayed female Siamese cat with a three-and-a-half year history of progressive cutaneous depigmentation are described. Clinically the condition was characterised by progressive leukoderma of the nose, pinna and footpad skin, and multifocal leukotrichia involving the whole body. Histopathological and ultrastructural studies confirmed the absence of melanocytes and melanin in the epidermis and hair follicles of affected areas. Immunohistochemical study revealed areas with absence of immune response to anti-vimentin antiserum, which was interpreted as a loss of dendritic cells, especially melanocytes. Diagnosis of vitiligo was based on the clinical signs and pathological features. This study adds a new case of this uncommon condition in the cat, and documents some previously non-reported features of feline vitiligo, such as the chronic progressive and generalised nature of the skin lesions, and its reversible character with partial lentiginous repigmentation on the pinna.
- Published
- 1994
- Full Text
- View/download PDF
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