1. Baricitinib reduces 30-day mortality in older adults with moderate-to-severe COVID-19 pneumonia.
- Author
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Abizanda P, Calbo Mayo JM, Mas Romero M, Cortés Zamora EB, Tabernero Sahuquillo MT, Romero Rizos L, Sánchez-Jurado PM, Sánchez-Nievas G, Campayo Escolano C, Ochoa Serrano A, Sánchez-Flor Alfaro V, López Bru R, Gómez Ballesteros C, Caldevilla Bernardo D, Callejas González FJ, Andrés-Pretel F, Lauschke VM, and Stebbing J
- Subjects
- Age Factors, Aged, Aged, 80 and over, Antiviral Agents administration & dosage, Antiviral Agents adverse effects, Female, Hospital Mortality, Humans, Janus Kinase Inhibitors administration & dosage, Janus Kinase Inhibitors adverse effects, Male, Mortality, Outcome and Process Assessment, Health Care, SARS-CoV-2 isolation & purification, Severity of Illness Index, Spain epidemiology, Azetidines administration & dosage, Azetidines adverse effects, COVID-19 mortality, COVID-19 physiopathology, Pneumonia, Viral diagnosis, Pneumonia, Viral drug therapy, Purines administration & dosage, Purines adverse effects, Pyrazoles administration & dosage, Pyrazoles adverse effects, Sulfonamides administration & dosage, Sulfonamides adverse effects, COVID-19 Drug Treatment
- Abstract
Background: Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia., Methods: This is a propensity score [PS]-matched retrospective cohort study. Patients from the COVID-AGE and Alba-Score cohorts, hospitalized for moderate-to-severe COVID-19 pneumonia, were categorized in two age brackets of age <70 years old (86 with baricitinib and 86 PS-matched controls) or ≥70 years old (78 on baricitinib and 78 PS-matched controls). Thirty-day mortality rates were analyzed with Kaplan-Meier and Cox proportional hazard models., Results: Mean age was 79.1 for those ≥70 years and 58.9 for those <70. Exactly 29.6% were female. Treatment with baricitinib resulted in a significant reduction in death from any cause by 48% in patients aged 70 or older, an 18.5% reduction in 30-day absolute mortality risk (n/N: 16/78 [20.5%] baricitinib, 30/78 [38.5%] in PS-matched controls, p < 0.001) and a lower 30-day adjusted fatality rate (HR 0.21; 95% CI 0.09-0.47; p < 0.001). Beneficial effects on mortality were also observed in the age group <70 (8.1% reduction in 30-day absolute mortality risk; HR 0.14; 95% CI 0.03-0.64; p = 0.011)., Conclusions: Baricitinib is associated with an absolute mortality risk reduction of 18.5% in adults older than 70 years hospitalized with COVID-19 pneumonia., (© 2021 The American Geriatrics Society.)
- Published
- 2021
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