1. Lethal synergy between sarcoma-180/TG cells and vesicular stomatitis virus in mice.
- Author
-
Deig EF, Cranford RE, Riedlinger DJ, and Akers TG
- Subjects
- Animals, Dibenzylchlorethamine pharmacology, Female, Hypersensitivity, Mice, Neoplasm Transplantation, Sarcoma 180 immunology, Serotonin pharmacology, Serotonin Antagonists, Vesicular stomatitis Indiana virus immunology, Sarcoma 180 mortality, Vesicular stomatitis Indiana virus growth & development
- Abstract
An interaction between sarcoma-180/TG cells and vesicular stomatitis virus in adult mice resulted in the rapid onset of extensive mortality. This interaction, termed lethal synergy, occurred only at early stages of ascites induction in animals with no prior virus contact. A significant sparing effect conferred by the serotonin antagonist dibenamine was reversed by the administration of serotonin. The cause of death was not determined, but a mechanism involving hypersensitivity is indicated.
- Published
- 1975
- Full Text
- View/download PDF