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Background: Healthcare consumers require diverse resources to assist their navigation of complex healthcare interactions, however, these resources need to be fit for purpose., Aim: In this study, we evaluated the utility, usability and feasibility of children, families and adults requiring long-term intravenous therapy using a recently developed mobile health application (App), intravenous (IV) Passport., Design: Multi-site, parallel, multi-method, prospective cohort study., Methods: A multi-site, multi-method study was carried out in 2020-2021, with 46 participants (20 adults, 26 children/family) reporting on their experiences surrounding the use of the IV Passport for up to 6 months., Results: Overall, utility rates were acceptable, with 78.3% (N = 36) using the IV Passport over the follow-up period, with high rates of planned future use for those still active in the project (N = 21; 73%), especially in the child/family cohort (N = 13; 100%). Acceptability rates were high (9/10; IQR 6.5-10), with the IV Passport primarily used for documenting new devices and complications. Thematic analysis revealed three main themes (and multiple subthemes) in the qualitative data: Advocacy for healthcare needs, Complexity of healthcare and App design and functionality., Conclusion: Several recommendations were made to improve the end-user experience including 'how to' instructions; and scheduling functionality for routine care., Implications for the Profession And/or Patient Care: The IV Passport can be safely and appropriately integrated into healthcare, to support consumers., Impact: Patient-/parent-reported feedback suggests the Intravenous Passport is a useful tool for record-keeping, and positive communication between patients/parents, and clinicians., Reporting Method: Not applicable., Patient Contribution: Consumers reported their experiences surrounding the use of the IV Passport for up to 6 months., (© 2024 The Authors. Journal of Clinical Nursing published by John Wiley & Sons Ltd.)