1. 4D flow cardiovascular magnetic resonance for monitoring of aortic valve repair in bicuspid aortic valve disease
- Author
-
Johannes Petersen, Peter Bannas, Yskert von Kodolitsch, Hermann Reichenspurner, Hendrik Kooijman, Alexander Lenz, Gerhard Adam, Evaldas Girdauskas, Julius Matthias Weinrich, Christoph Riedel, and Bjoern P. Schoennagel
- Subjects
Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,Time Factors ,Heart Valve Diseases ,Hemodynamics ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Bicuspid aortic valve ,Aortic valve repair ,Bicuspid Aortic Valve Disease ,Thoracic aorta ,Adult congenital heart disease ,Prospective Studies ,Aortic valve regurgitation ,Aorta ,Radiological and Ultrasound Technology ,Middle Aged ,Bicuspid aortopathy ,Treatment Outcome ,Aortic Valve ,Cardiology ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,Blood Flow Velocity ,Adult ,medicine.medical_specialty ,Aortic Valve Insufficiency ,Magnetic Resonance Imaging, Cine ,Aortic regurgitation ,Aortography ,Cardiac Valve Annuloplasty ,03 medical and health sciences ,Young Adult ,Predictive Value of Tests ,Internal medicine ,medicine.artery ,Ascending aorta ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,ddc:610 ,Congenital heart disease ,4D flow MRI ,business.industry ,Research ,Recovery of Function ,medicine.disease ,lcsh:RC666-701 ,Feasibility Studies ,Unicuspid ,business - Abstract
Background Aortic valve repair has become a treatment option for adults with symptomatic bicuspid (BAV) or unicuspid (UAV) aortic valve insufficiency. Our aim was to demonstrate the feasibility of 4D flow cardiovascular magnetic resonance (CMR) to assess the impact of aortic valve repair on changes in blood flow dynamics in patients with symptomatic BAV or UAV. Methods Twenty patients with adult congenital heart disease (median 35 years, range 18–64; 16 male) and symptomatic aortic valve regurgitation (15 BAV, 5 UAV) were prospectively studied. All patients underwent 4D flow CMR before and after aortic valve repair. Aortic valve regurgitant fraction and systolic peak velocity were estimated. The degree of helical and vortical flow was evaluated according to a 3-point scale. Relative flow displacement and wall shear stress (WSS) were quantified at predefined levels in the thoracic aorta. Results All patients underwent successful aortic valve repair with a significant reduction of aortic valve regurgitation (16.7 ± 9.8% to 6.4 ± 4.4%, p p = 0.014). Both helical flow (1.6 ± 0.6 vs. 0.9 ± 0.5, p p = 0.002) as well as both flow displacement (0.3 ± 0.1 vs. 0.25 ± 0.1, p = 0.031) and WSS (0.8 ± 0.2 N/m2 vs. 0.5 ± 0.2 N/m2, p Conclusions 4D flow CMR allows assessment of the impact of aortic valve repair on changes in blood flow dynamics in patients with bicuspid aortic valve disease.
- Published
- 2020
- Full Text
- View/download PDF