1. Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial
- Author
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Helen J Martin, Jessica Horton, Soren Brage, Alison Sleigh, Simon J. Griffin, Lisa R Purslow, Nicholas J. Wareham, Kenneth Horton, Avan Aihie Sayer, David B. Savage, Francis M. Finucane, Cyrus Cooper, Hervé Besson, Ulf Ekelund, Stephen J. Sharp, Ema De Lucia Rolfe, Savage, David [0000-0002-7857-7032], Brage, Soren [0000-0002-1265-7355], Sharp, Stephen [0000-0003-2375-1440], Griffin, Simon [0000-0002-2157-4797], Wareham, Nicholas [0000-0003-1422-2993], and Apollo - University of Cambridge Repository
- Subjects
Aging ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Trials and Supportive Activities ,Psychological intervention ,030209 endocrinology & metabolism ,Cardiovascular ,Metabolic and Endocrine ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,1117 Public Health and Health Services ,law.invention ,Clinical ,Study Protocol ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Clinical Research ,law ,Diabetes mellitus ,Medicine ,Aerobic exercise ,Obesity ,030212 general & internal medicine ,Nutrition ,6.7 Physical ,lcsh:RC648-665 ,business.industry ,Prevention ,1103 Clinical Sciences ,General Medicine ,Anthropometry ,medicine.disease ,Clinical Medicine and Science ,Low birth weight ,Physical therapy ,Observational study ,medicine.symptom ,business ,3.1 Primary prevention interventions to modify behaviours or promote well-being ,Cohort study - Abstract
Background: While there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve insulin sensitivity in older people has not been fully elucidated. Furthermore, while low birth weight has been shown to predict adverse health outcomes later in life, its influence on the response to aerobic exercise is unknown. Our primary objective is to assess the efficacy of a fully supervised twelve week aerobic exercise intervention in reducing clustered metabolic risk in healthy older adults. A secondary objective is to determine the influence of low birth weight on the response to exercise in this group. Methods/Design: We aim to recruit 100 participants born between 1931–1939, from the Hertfordshire Cohort Study and randomly assign them to no intervention or to 36 fully supervised one hour sessions on a cycle ergometer, over twelve weeks. Each participant will undergo detailed anthropometric and metabolic assessment pre- and post-intervention, including muscle biopsy, magnetic resonance imaging and spectroscopy, objective measurement of physical activity and sub-maximal fitness testing. Discussion: Given the extensive phenotypic characterization, this study will provide valuable insights into the mechanisms underlying the beneficial effects of aerobic exercise as well as the efficacy, feasibility and safety of such interventions in this age group. Trial Registration: Current Controlled Trials: ISRCTN60986572
- Published
- 2009