1. Immunohistochemical features of multifocal melanoacanthoma in the hard palate: a case report
- Author
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Adriana Aigotti Haberbeck Brandão, Luiz Antonio Guimarães Cabral, Vitor Hugo Farina, Luis Felipe das Chagas e Silva de Carvalho, Janete Dias Almeida, Ricardo D. Coletta, Universidade Estadual Paulista (Unesp), Federal University of ABC, and Universidade Estadual de Campinas (UNICAMP)
- Subjects
Palate, Hard ,Pathology ,medicine.medical_specialty ,lcsh:Medicine ,Case Report ,acanthoma ,General Biochemistry, Genetics and Molecular Biology ,Lesion ,hard palate ,medicine ,mouth tumor ,case report ,Humans ,human ,Oral mucosa ,lcsh:Science (General) ,lcsh:QH301-705.5 ,Mouth neoplasm ,Medicine(all) ,Mouth ,Melanoacanthoma ,business.industry ,Biochemistry, Genetics and Molecular Biology(all) ,Melanoma ,lcsh:R ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,medicine.anatomical_structure ,female ,lcsh:Biology (General) ,Acanthoma ,Pigmented lesions ,Female ,pathology ,Mouth Neoplasms ,Hard palate ,medicine.symptom ,Differential diagnosis ,business ,metabolism ,lcsh:Q1-390 - Abstract
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:28:16Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:32:16Z : No. of bitstreams: 1 2-s2.0-84872764879.pdf: 1974358 bytes, checksum: 3777a58ae1a490980c52d35ae5548b1a (MD5) Made available in DSpace on 2014-05-27T11:28:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-30 Background: Melanoacanthoma (MA) has been described in the oral mucosa as a solitary lesion or, occasionally, as multiple lesions. MA mainly affects dark skinned patients and grows rapidly, showing a plane or slightly raised appearance and a brown to black color. The differential diagnosis includes oral nevi, amalgam tattoos, and melanomas. We report here the case of a 58-year-old black woman who presented multiple pigmented lesions on the hard palate. Case presentation. Based on the differential diagnosis of melanoma, a punch biopsy (4 mm in diameter) was performed. The material was fixed in 10% formalin, embedded in paraffin, and stained with hematoxylin-eosin or submitted to immunohistochemical analysis. Immunohistochemistry using antibodies against protein S-100, melan-A, HMB-45, MCM-2, MCM-5, Ki-67 and geminin was performed. Immunohistochemical analysis revealed strong cytoplasmic immunoreactivity of dendritic melanocytes for proteinS-100, HMB-45 and melan-A.Positive staining for proliferative markers (MCM-2, MCM-5, Ki-67) was only observed in basal and suprabasal epithelial cells, confirming the reactive etiology of the lesion. The diagnosis was oral Melanoacanthoma (MA). Conclusion: The patient has been followed up for 30 months and shows no clinical alterations. MA should be included in the differential diagnosis of pigmented lesions of the oral cavity. © 2013 das Chagas e Silva de Carvalho et al.; licensee BioMed Central Ltd. Department of Biosciences and Oral Diagnosis São José Dos Campos Dental School São Paulo State University (UNESP), São Paulo Nanosciences and Advanced Materials Federal University of ABC, Santo André, São Paulo Department of Oral Diagnosis Piracicaba Dental School University of Campinas, Piracicaba, São Paulo Faculdade de Odontologia de São José Dos Campos - UNESP Departamento de Biociências e Diagnóstico Bucal, Av. Francisco José Longo, 777 São Dimas, 12245-000, Sao Jose dos Campos, Sao Paulo Department of Biosciences and Oral Diagnosis São José Dos Campos Dental School São Paulo State University (UNESP), São Paulo Faculdade de Odontologia de São José Dos Campos - UNESP Departamento de Biociências e Diagnóstico Bucal, Av. Francisco José Longo, 777 São Dimas, 12245-000, Sao Jose dos Campos, Sao Paulo
- Published
- 2013