1. Maternal exposure to air pollution before and during pregnancy related to changes in newborn's cord blood lymphocyte subpopulations. The EDEN study cohort
- Author
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Isabella Annesi-Maesano, Marie-Nathalie Kolopp-Sarda, Olivier Thiebaugeorges, Marie-Christine Béné, Gilbert C. Faure, Antoine Magnan, Marie-Aline Charles, Rémy Slama, Nour Baïz, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Immunologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité (RCV), Université Henri Poincaré - Nancy 1 (UHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], The assessment of exposure to atmospheric pollutants was supported by a grant from the French Agency for Environment Security (AFFSET). We acknowledge all the funding sources for the EDEN study: Fondation pour la Recherche Médicale (FRM), French Ministry of Research: IFR program, INSERM Nutrition Research Program, French Ministry of Health Perinatality Program,French Agency for Environment Security (AFFSET), French National Institute for Population Health Surveillance (INVS), Paris-Sud University, French National Institute for Health Education (INPES), Nestlé, Mutuelle Générale de l'Education Nationale (MGEN), French speaking association for the study of diabetes and metabolism (Alfediam), National Agency for Research (ANR)., and BMC, Ed.
- Subjects
Male ,MESH: Air Pollutants ,Physiology ,MESH: Benzene ,MESH: Flow Cytometry ,010501 environmental sciences ,01 natural sciences ,Cohort Studies ,MESH: Pregnancy ,Pregnancy ,MESH: Gestational Age ,Obstetrics and Gynaecology ,MESH: Maternal Exposure ,MESH: Cohort Studies ,2. Zero hunger ,Air Pollutants ,0303 health sciences ,Obstetrics ,MESH: Infant, Newborn ,Obstetrics and Gynecology ,Gestational age ,Fetal Blood ,Flow Cytometry ,3. Good health ,medicine.anatomical_structure ,Maternal Exposure ,MESH: Young Adult ,Cord blood ,Cohort ,Female ,France ,MESH: Environmental Monitoring ,Environmental Monitoring ,Research Article ,Adult ,medicine.medical_specialty ,MESH: Air Pollution ,Offspring ,MESH: Lymphocyte Subsets ,Gestational Age ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,lcsh:Gynecology and obstetrics ,Young Adult ,03 medical and health sciences ,Air Pollution ,Placenta ,medicine ,Humans ,MESH: Fetal Blood ,lcsh:RG1-991 ,030304 developmental biology ,0105 earth and related environmental sciences ,Asthma ,Fetus ,MESH: Humans ,business.industry ,Infant, Newborn ,Benzene ,MESH: Adult ,medicine.disease ,Lymphocyte Subsets ,MESH: Male ,MESH: France ,[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,13. Climate action ,business ,MESH: Female - Abstract
Background Toxicants can cross the placenta and expose the developing fetus to chemical contamination leading to possible adverse health effects, by potentially inducing alterations in immune competence. Our aim was to investigate the impacts of maternal exposure to air pollution before and during pregnancy on newborn's immune system. Methods Exposure to background particulate matter less than 10 μm in diameter (PM10) and nitrogen dioxide (NO2) was assessed in 370 women three months before and during pregnancy using monitoring stations. Personal exposure to four volatile organic compounds (VOCs) was measured in a subsample of 56 non-smoking women with a diffusive air sampler during the second trimester of pregnancy. Cord blood was analyzed at birth by multi-parameter flow cytometry to determine lymphocyte subsets. Results Among other immunophenotypic changes in cord blood, decreases in the CD4+CD25+ T-cell percentage of 0.82% (p = 0.01), 0.71% (p = 0.04), 0.88% (p = 0.02), and 0.59% (p = 0.04) for a 10 μg/m3 increase in PM10 levels three months before and during the first, second and third trimester of pregnancy, respectively, were observed after adjusting for confounders. A similar decrease in CD4+CD25+ T-cell percentage was observed in association with personal exposure to benzene. A similar trend was observed between NO2 exposure and CD4+CD25+ T-cell percentage; however the association was stronger between NO2 exposure and an increased percentage of CD8+ T-cells. Conclusions These data suggest that maternal exposure to air pollution before and during pregnancy may alter the immune competence in offspring thus increasing the child's risk of developing health conditions later in life, including asthma and allergies.
- Published
- 2011
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