1. Clinical and prognostic associations of anti-Jo-1 antibody levels in patients with antisynthetase syndrome
- Author
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Hongxia Yang, Qingning Chen, Chao Sun, Qiwen Jin, Lining Zhang, Qingyan Liu, Qinglin Peng, Guochun Wang, and Xin Lu
- Subjects
Anti-Jo-1 antibody levels ,Antisynthetase syndrome ,Disease activity ,Prognosis ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Objective To investigate the association of serum anti-Jo-1 antibody levels with the disease activity and prognosis in anti-Jo-1-positive patients with antisynthetase syndrome (ASS). Methods This study included 115 anti-Jo-1-positive patients with ASS who were admitted to China-Japan Friendship Hospital between 2009 and 2019. Anti-Jo-1 antibody serum levels at initial admission and follow-up were determined by enzyme-linked immunosorbent assay (ELISA). Global and organ disease activity was assessed at baseline and follow-up according to the International Myositis Assessment and Clinical Studies guidelines. Results Among enrolled patients, 70 (60.9%) patients initially presented with interstitial lung disease (ILD), and 46 (40%) patients presented with with muscle weakness at initial admission. At baseline, patients with ILD had lower levels of anti-Jo-1 antibodies than those without ILD (p = 0.012). Baseline anti-Jo-1 antibody levels were higher in patients with muscle weakness, skin involvement, and arthritis (all p
- Published
- 2024
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