1. Risk stratification based on screening history: the NELSON lung cancer screening study
- Author
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Carlijn M. van der Aalst, Kristiaan Nackaerts, Pim A. de Jong, Uraujh Yousaf-Khan, Matthijs Oudkerk, Kevin ten Haaf, Ernst T. Scholten, Marjolein A Heuvelmans, Harry J.M. Groen, Harry J. de Koning, Joan Walter, Rozemarijn Vliegenthart, Public Health, Erasmus MC other, Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), and Cardiovascular Centre (CVC)
- Subjects
Male ,Lung Neoplasms ,PREDICTION ,medicine.medical_treatment ,Smoking cessation ,law.invention ,0302 clinical medicine ,Belgium ,Randomized controlled trial ,Risk Factors ,law ,Clinical Epidemiology ,PULMONARY NODULES ,Early Detection of Cancer ,Netherlands ,Smoking ,Lung Cancer ,Age Factors ,SELECTION CRITERIA ,Middle Aged ,Multicenter Study ,PROBABILITY ,Ct screening ,030220 oncology & carcinogenesis ,Randomized Controlled Trial ,Indeterminate result ,Risk stratification ,TRIAL ,Female ,Indeterminate ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Tobacco and the lung ,Risk Assessment ,LOW-DOSE CT ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Internal medicine ,MANAGEMENT ,Journal Article ,medicine ,INTERVAL ,Humans ,Lung cancer ,Aged ,Gynecology ,business.industry ,MORTALITY ,medicine.disease ,PRESPECIFI ED ANALYSIS ,030228 respiratory system ,Tomography, X-Ray Computed ,business ,Lung cancer screening ,Follow-Up Studies - Abstract
Background Debate about the optimal lung cancer screening strategy is ongoing. In this study, previous screening history of the Dutch-Belgian Lung Cancer Screening trial (NELSON) is investigated on if it predicts the screening outcome (test result and lung cancer risk) of the final screening round. Methods 15â €..792 participants were randomised (1:1) of which 7900 randomised into a screening group. CT screening took place at baseline, and after 1, 2 and 2.5â €..years. Initially, three screening outcomes were possible: negative, indeterminate or positive scan result. Probability for screening outcome in the fourth round was calculated for subgroups of participants. Results Based on results of the first three rounds, three subgroups were identified: (1) those with exclusively negative results (n=3856; 73.0%); (2) those with ≥1 indeterminate result, but never a positive result (n=1342; 25.5%); and (3) with ≥1 positive result (n=81; 1.5%). Group 1 had the highest probability for having a negative scan result in round 4 (97.2% vs 94.8% and 90.1%, respectively, p
- Published
- 2017
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