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Your search keyword '"Iodice, Valeria"' showing total 17 results
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17 results on '"Iodice, Valeria"'

1. Multidisciplinary consensus guideline for the diagnosis and management of spontaneous intracranial hypotension

Author

Cheema, Sanjay, primary, Anderson, Jane, additional, Angus-Leppan, Heather, additional, Armstrong, Paul, additional, Butteriss, David, additional, Carlton Jones, Lalani, additional, Choi, David, additional, Chotai, Amar, additional, D'Antona, Linda, additional, Davagnanam, Indran, additional, Davies, Brendan, additional, Dorman, Paul J, additional, Duncan, Callum, additional, Ellis, Simon, additional, Iodice, Valeria, additional, Joy, Clare, additional, Lagrata, Susie, additional, Mead, Sarah, additional, Morland, Danny, additional, Nissen, Justin, additional, Pople, Jenny, additional, Redfern, Nancy, additional, Sayal, Parag P, additional, Scoffings, Daniel, additional, Secker, Russell, additional, Toma, Ahmed K, additional, Trevarthen, Tamsin, additional, Walkden, James, additional, Beck, Jürgen, additional, Kranz, Peter George, additional, Schievink, Wouter, additional, Wang, Shuu-Jiun, additional, and Matharu, Manjit Singh, additional

Published
2023
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2. Survey of healthcare professionals’ knowledge, attitudes and practices regarding spontaneous intracranial hypotension

Author

Cheema, Sanjay, primary, Anderson, Jane, additional, Duncan, Callum, additional, Davagnanam, Indran, additional, Armstrong, Paul, additional, Redfern, Nancy, additional, Ordman, Anthony, additional, D’Antona, Linda, additional, Nissen, Justin, additional, Sayal, Parag, additional, Vaughan-Huxley, Eyston, additional, Lagrata, Susie, additional, Iodice, Valeria, additional, Snape-Burns, Jessica, additional, Joy, Clare, additional, and Matharu, Manjit, additional

Published
2022
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11. 037 New insight into dysautonomia in GFAP astrocytopathy

Author

Goh, Yee Yen, primary, Koay, Shiwen, additional, Goodall, Jack, additional, Oommens, Grace, additional, Ingle, Gordon, additional, Parris, Victoria, additional, Iodice, Valeria, additional, Swanton, Josephine, additional, and McNamara, Patricia, additional

Published
2022
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14. 293 Autoimmune autonomic ganglionopathy: the NHNN experience

Author

Watson Laura, Lang Bethan, Bremner Fion, Lunn Michael, Hagen Ellen Merete, Iodice Valeria, Ingle Gordon, Koay Shiwen, Vincent Angela, and Mathias Christopher

Subjects
medicine.medical_specialty, Neurology, business.industry, Autonomic ganglion, Autoimmune autonomic ganglionopathy, medicine.disease, Gastroenterology, Sudomotor, Psychiatry and Mental health, Orthostatic vital signs, Autonomic nervous system, medicine.anatomical_structure, Internal medicine, Medicine, Surgery, Rituximab, Neurology (clinical), business, Pure autonomic failure, medicine.drug
Abstract

BackgroundAutoimmune Autonomic Ganglionopathy (AAG) is a rare, immune-mediated condition characterised by subacute pandysautonomia. 50% have auto-antibodies to the ganglionic nicotinic acetylcholine receptor (gAChR), affecting synaptic transmission at autonomic ganglia.MethodsWe describe 13 patients (5 female, median age 47) presenting with widespread autonomic failure, confirmed on cardiovascular, sudomotor and pupillometry testing at the National Hospital for Neurology and Neurosurgery (NHNN), and high gAChR antibody levels (>200 pm) measured by radioimmunoprecipitation assay at Oxford University.ResultsOf the 13 patients, 8 had other autoimmune conditions, 3 had antecedent infection and 3 were paraneoplastic. All had orthostatic hypotension, gastro-intestinal and urinary symptoms, 11 had documented pupillary abnormalities (9 mixed sympathetic and parasympathetic deficits, 2 subclinical sympathetic deficits), 11 had secretomotor dysfunction, 8 had generalised/partial anhidrosis, 8 had sexual dysfunction and 7 had evidence of small fibre dysfunction on neurophysiology.Ten received immunomodulatory treatment; 6 plasma exchange and 4 combination treatment including intravenous immunoglobulin, mycophenolate and rituximab. Earlier treatment was associated with greater clinical response.DiscussionPatients with AAG and high gAChR antibody levels have widespread dysfunction of the autonomic nervous system, which can respond dramatically to immunomodulation. Further research is needed to develop robust clinical biomarkers to guide treatment and monitor response.

Published
2018

15. THUR 155 Autonomic function testing in autoimmune autonomic ganglionopathies

Author

Skeavington Ian, Vichayanrat Ekawat, Iodice Valeria, Hagen Ellen Merete, Almeida Nadine, Ingle Gorgon, and Vivekanandam Vinojini

Subjects
Autonomic function, medicine.medical_specialty, Treatment response, business.industry, Gold standard, Diastole, Diaphragmatic breathing, medicine.disease, Psychiatry and Mental health, Orthostatic vital signs, Internal medicine, Heart rate, Cardiology, Medicine, Surgery, Neurology (clinical), business, Pure autonomic failure
Abstract

IntroductionAutoimmune autonomic ganglionopathies (AAG) are an increasingly diagnosed cause of autonomic failure. In 50% of patients, nicotinic ganglionic acetylcholine receptor (α3-AchR) antibodies are found. The presentation includes orthostatic hypotension, gastrointestinal and bladder dysfunction, abnormal pupillary responses and sicca symptoms. Physiological changes are documented with serial autonomic function testing. Gold standard therapy is not well established; however treatment with repeated plasma exchange appears to alter disease course.We provide the first description of consecutive autonomic function tests of one patient with seronegative AAG versus one patient with seropositive AAG both treated with serial plasma exchanges.MethodsWe compare ten parameters – time tolerated in head up tilt (HUT), lowest tilt heart rate (HR), systolic and diastolic blood pressures (BP), HR Valsalva phase 2 and 4, Valsalva ratio, change in catecholamines, HR response to deep breathing and antibody titre.ResultsHUT time, Valsalva ratio and the lowest tilt diastolic BP correlate best with clinical course over time. The α3-AchR titre also correlates with clinical improvement in the seropositive AAG patient. ConclusionsWe propose that repeated HUT time, Valsalva ratio and lowest tilt diastolic BP should be recorded in patients with AAG to determine treatment response and to assist in deciding treatment continuation.

Published
2018

16. THUR 120 Postprandial hypotension in MSA and PD with autonomic failure

Author

Hagen Ellen Merete, Ingle Gordon, Mathias Christopher, Iodice Valeria, and Vichayanrat Ekawat

Subjects
medicine.medical_specialty, Supine position, business.industry, digestive, oral, and skin physiology, medicine.disease, Psychiatry and Mental health, Orthostatic vital signs, Blood pressure, Atrophy, Postprandial, Internal medicine, Heart rate, medicine, Cardiology, Ingestion, Surgery, Neurology (clinical), Pure autonomic failure, business
Abstract

IntroductionPostprandial hypotension is often reported in Parkinson’s disease with autonomic failure (PD+AF) and Multiple System Atrophy (MSA). However there has been no study directly comparing this feature between these two disorders. The aim of this study was to evaluate cardiovascular autonomic responses before and after standard liquid meal ingestion in PD+AF and MSA.MethodsPatients underwent a liquid meal challenge using a previously described protocol. Blood pressure (BP) and heart rate (HR) were measured at intervals. All participants remained supine for 45 min after the liquid meal ingestion. They underwent 10 min head-up tilt (HUT) to 60° before and 45 min after the meal.Results22 MSA and 11 PD+AF patients were identified. Supine post-prandial hypotension was significantly more common in PD+AF compared to MSA (73% vs 36%; p0.05).ConclusionDespite the similar degree of orthostatic hypotension on supine and HUT, postprandial hypotension is more commonly present in patients with PD+AF compared to MSA. The increased tendency to post-prandial hypotension even while supine reflects the nature of post-ganglionic sympathetic denervation in PD.

Published
2018

17. Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests

Author

Iodice, Valeria, primary, Lipp, Axel, additional, Ahlskog, J Eric, additional, Sandroni, Paola, additional, Fealey, Robert D, additional, Parisi, Joseph E, additional, Matsumoto, Joseph Y, additional, Benarroch, Eduardo E, additional, Kimpinski, Kurt, additional, Singer, Wolfgang, additional, Gehrking, Tonette L, additional, Gehrking, Jade A, additional, Sletten, David M, additional, Schmeichel, Ann M, additional, Bower, James H, additional, Gilman, Sid, additional, Figueroa, Juan, additional, and Low, Phillip A, additional

Published
2012
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