1. Early markers of neurodevelopmental disorders based on general movements for very preterm infants: study protocol for a multicentre prospective cohort study in a clinical setting in China
- Author
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Jun Wang, Xiushu Shen, Hong Yang, Zhihua Li, Shuyi Liang, Furong Wu, Xinglu Tang, Xujie Mao, Minsi He, Fengdan Xu, Xueyan Li, Chengmei Li, Shuangshuang Qian, Xiaoyun Zhu, Fanzhe Meng, Yun Wu, Herong Gao, Jiayan Cao, Huanhuan Yin, Yin Wang, and Yanxiang Huang
- Subjects
General Medicine - Abstract
IntroductionVery preterm (VPT) infants may experience varying degrees of neurodevelopmental challenges. Lack of early markers for neurodevelopmental disorders may delay referral to early interventions. The detailed General Movements Assessment (GMA) could help us to identify early markers for VPT infants at risk of atypical neurodevelopmental clinical phenotype in the very early stage of life as soon as possible. Preterm infants with high risk of atypical neurodevelopmental outcomes will have the best possible start to life if early precise intervention in critical developmental windows is allowed.Methods and analysisThis is a nationwide, multicentric prospective cohort study that will recruit 577 infants born Ethics and disseminationThe central ethical approval has been confirmed from the Research Ethical Board of Children’s Hospital of Fudan University (ref approval no. 2022(029)) and the local ethical approval has been also obtained by the corresponding ethics committees of the recruitment sites. Critical analysis of the study results will contribute to providing a basis for hierarchical management and precise intervention for preterm infants in very early life.Trial registration numberChiCTR2200064521.
- Published
- 2023
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