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20 results on '"López-Mejías, R."'

1. AB0173 MUCOSAL IMMUNE DEFENCE POLYMORPHISMS: RELEVANT PLAYERS IN IGA VASCULITIS?

Author

Pulito-Cueto, V., primary, Remuzgo Martinez, S., additional, Genre Romero, F., additional, Sevilla, B., additional, Ortego, N., additional, Leonardo, M., additional, Peñalba, A., additional, Narváez, J., additional, Martín-Penagos, L., additional, Belmar-Vega, L., additional, Gomez-Fernandez, C., additional, Sebastián Mora-Gil, M., additional, Caminal Montero, L., additional, Collado, P., additional, De Argila, D., additional, Rodriguez-Jimenez, P., additional, Vicente-Rabaneda, E. F., additional, Rubio-Romero, E., additional, Leon Luque, M., additional, Blanco-Madrigal, J. M., additional, Galíndez-Agirregoikoa, E., additional, Martin Ibanez, J., additional, Castañeda, S., additional, González-Gay, M. A., additional, Blanco, R., additional, and López-Mejías, R., additional

Published
2023
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2. AB0145 IgA VASCULITIS AND IgA NEPHROPATHY SHARE A SIMILAR IL33-IL1RL1 ASSOCIATION PATTERN

Author

Prieto-Peña, D., primary, Remuzgo Martinez, S., additional, Genre, F., additional, Pulito-Cueto, V., additional, Atienza-Mateo, B., additional, Sevilla, B., additional, Llorca, J., additional, Ortego, N., additional, Leonardo, M., additional, Peñalba, A., additional, Martín-Penagos, L., additional, Miranda Fillloy, J. A., additional, Narváez, J., additional, Caminal Montero, L., additional, Collado, P., additional, Fernandez-Nebro, A., additional, Díaz-Cordoves, G., additional, Cigarrán, S., additional, Calviño, J., additional, Cobelo, C., additional, Quiroga Colino, P., additional, Sanchez Perez, J., additional, Rubio-Romero, E., additional, Leon Luque, M., additional, Blanco-Madrigal, J. M., additional, Galíndez-Agirregoikoa, E., additional, Gualillo, O., additional, Martin Ibanez, J., additional, Castañeda, S., additional, Blanco, R., additional, González-Gay, M. A., additional, and López-Mejías, R., additional

Published
2022
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3. POS0405 INCREASED LEVELS OF CELLULAR ADHESION MOLECULES ARE LINKED TO THE PRESENCE OF INTERSTITIAL LUNG DISEASE IN PATIENTS WITH AUTOIMMUNE DISEASES

Author

Pulito-Cueto, V., primary, Remuzgo-Martínez, S., additional, Genre, F., additional, Atienza-Mateo, B., additional, Portilla, V., additional, Mora-Cuesta, V. M., additional, Iturbe Fernández, D., additional, Lera-Gómez, L., additional, Prieto-Peña, D., additional, Blanco, R., additional, Corrales, A., additional, Gualillo, O., additional, Cifrián-Martínez, J. M., additional, López-Mejías, R., additional, and González-Gay, M. A., additional

Published
2022
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4. POS0052 ANGIOGENIC T CELLS AS RELEVANT PLAYERS IN THE LUNG VASCULOPATHY OF RHEUMATOID ARTHRITIS, SYSTEMIC SCLEROSIS AND OTHER AUTOIMMUNE DISEASES

Author

Pulito-Cueto, V., primary, Remuzgo-Martínez, S., additional, Genre, F., additional, Atienza-Mateo, B., additional, Portilla, V., additional, Mora-Cuesta, V. M., additional, Iturbe Fernández, D., additional, Lera-Gómez, L., additional, Rodriguez Carrio, J., additional, Prieto-Peña, D., additional, Blanco, R., additional, Corrales, A., additional, Gualillo, O., additional, Cifrián-Martínez, J. M., additional, López-Mejías, R., additional, and González-Gay, M. A., additional

Published
2022
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5. AB0069 ASSOCIATION OF NUCLEAR FACTOR OF ACTIVATED T CELLS CYTOPLASMIC 1 (NFATc1) EXPRESSION WITH CARDIOVASCULAR RISK IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS

Author

Genre, F., primary, Pulito-Cueto, V., additional, Corrales, A., additional, Portilla, V., additional, Lera-Gómez, L., additional, Atienza-Mateo, B., additional, Gualillo, O., additional, Blanco, R., additional, Ferraz-Amaro, I., additional, Castañeda, S., additional, López-Mejías, R., additional, González-Gay, M. A., additional, and Remuzgo-Martínez, S., additional

Published
2022
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6. POS0327 IRISIN: A NEW MARKER OF SUBCLINICAL ATHEROSCLEROSIS, CARDIOVASCULAR RISK AND DISEASE ACTIVITY IN AXIAL SPONDYLOARTHRITIS?

Author

Remuzgo-Martínez, S., primary, Rueda-Gotor, J., additional, Pulito-Cueto, V., additional, López-Mejías, R., additional, Corrales, A., additional, Lera-Gómez, L., additional, Pérez-Fernández, R., additional, Portilla, V., additional, Gonzalez-Mazon, I., additional, Blanco, R., additional, Expósito, R., additional, Mata, C., additional, Llorca, J., additional, Hernández-Hernández, V., additional, Rodríguez-Lozano, C., additional, Barbarroja Puerto, N., additional, Ortega Castro, R., additional, Vicente-Rabaneda, E. F., additional, Fernández-Carballido, C., additional, Martínez-Vidal, M. P., additional, Castro-Corredor, D., additional, Anino-Fernández, J., additional, Peiteado, D., additional, Plasencia, C., additional, Galindez, E., additional, García Vivar, M. L., additional, Vegas-Revenga, N., additional, Urionaguena, I., additional, Gualillo, O., additional, Quevedo-Abeledo, J. C., additional, Castañeda, S., additional, Ferraz-Amaro, I., additional, González-Gay, M. A., additional, and Genre, F., additional

Published
2022
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7. AB0146 BAFF, APRIL y BAFFR: DIFFERENTIAL BIOMARKERS BETWEEN IgA VASCULITIS AND IgA NEPHROPATHY?

Author

Prieto-Peña, D., primary, Genre, F., additional, Remuzgo Martinez, S., additional, Pulito-Cueto, V., additional, Atienza-Mateo, B., additional, Sevilla, B., additional, Llorca, J., additional, Ortego, N., additional, Leonardo, M., additional, Peñalba, A., additional, Martín-Penagos, L., additional, Miranda Fillloy, J. A., additional, Narváez, J., additional, Caminal Montero, L., additional, Collado, P., additional, Fernandez-Nebro, A., additional, Díaz-Cordoves, G., additional, Cigarrán, S., additional, Calviño, J., additional, Cobelo, C., additional, De Argila, D., additional, Vicente-Rabaneda, E. F., additional, Rubio-Romero, E., additional, Leon Luque, M., additional, Blanco-Madrigal, J. M., additional, Galíndez-Agirregoikoa, E., additional, Gualillo, O., additional, Martin Ibanez, J., additional, Castañeda, S., additional, Blanco, R., additional, González-Gay, M. A., additional, and López-Mejías, R., additional

Published
2022
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8. POS0627 SHORT-TERM EFFECT OF ANTI-IL-6 THERAPY ON ADIPONECTIN SERUM LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Author

Remuzgo-Martínez, S., primary, Pulito-Cueto, V., additional, Genre, F., additional, Calvo, J., additional, Aurrecoechea, E., additional, Llorente, I., additional, Triguero-Martinez, A., additional, Blanco, R., additional, Llorca, J., additional, Ruiz, M. E., additional, Rivera, N., additional, Gualillo, O., additional, López-Mejías, R., additional, Castañeda, S., additional, and González-Gay, M. A., additional

Published
2021
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9. POS0113 BAFF-APRIL-BAFFR PATHWAY ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS

Author

Prieto-Peña, D., primary, Remuzgo Martinez, S., additional, Genre, F., additional, Pulito-Cueto, V., additional, Atienza-Mateo, B., additional, Sevilla, B., additional, Llorca, J., additional, Ortego, N., additional, Lera-Gómez, L., additional, Leonardo, M., additional, Peñalba, A., additional, Narváez, J., additional, Martín-Penagos, L., additional, Miranda-Filloy, J. A., additional, Caminal Montero, L., additional, Collado, P., additional, Sanchez Perez, J., additional, De Argila, D., additional, Rubio-Romero, E., additional, Leon Luque, M., additional, Blanco-Madrigal, J. M., additional, Galindez, E., additional, Martin Ibanez, J., additional, Castañeda, S., additional, Blanco, R., additional, González-Gay, M. A., additional, and López-Mejías, R., additional

Published
2021
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10. AB0070 ROLE OF VASPIN IN ATHEROSCLEROTIC DISEASE AND CARDIOVASCULAR RISK IN AXIAL SPONDYLOARTHRITIS

Author

Rueda-Gotor, J., primary, López-Mejías, R., additional, Remuzgo-Martínez, S., additional, Pulito Cueto, V., additional, Corrales, A., additional, Lera-Gómez, L., additional, Portilla, V., additional, González-Mazón, I., additional, Blanco, R., additional, Expósito, R., additional, Mata, C., additional, Llorca, J., additional, Hernández-Hernández, V., additional, Rodríguez-Lozano, C., additional, Barbarroja Puerto, N., additional, Ortega Castro, R., additional, García Castañeda, N., additional, Fernández-Carballido, C., additional, Martínez-Vidal, M. P., additional, Castro-Corredor, D., additional, Anino-Fernández, J., additional, Peiteado, D., additional, Plasencia, C., additional, Galindez, E., additional, García Vivar, M. L., additional, Gualillo, O., additional, Quevedo-Abeledo, J. C., additional, Castañeda, S., additional, Ferraz-Amaro, I., additional, González-Gay, M. A., additional, and Genre, F., additional

Published
2021
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11. AB0096 IGA VASCULITIS AND IGA NEPHROPATHY SHARE A SIMILAR IL17A ASSOCIATION PATTERN

Author

Prieto-Peña, D., primary, Genre, F., additional, Remuzgo Martinez, S., additional, Pulito-Cueto, V., additional, Atienza-Mateo, B., additional, Sevilla, B., additional, Llorca, J., additional, Ortego, N., additional, Lera-Gómez, L., additional, Leonardo, M., additional, Peñalba, A., additional, Martín-Penagos, L., additional, Miranda-Filloy, J. A., additional, Narváez, J., additional, Caminal Montero, L., additional, Collado, P., additional, Fernandez-Nebro, A., additional, Díaz-Cordoves, G., additional, Cigarrán, S., additional, Calviño, J., additional, Cobelo, C., additional, Sanchez Perez, J., additional, De Argila, D., additional, Rubio-Romero, E., additional, Leon Luque, M., additional, Blanco-Madrigal, J. M., additional, Galindez, E., additional, Martin Ibanez, J., additional, Castañeda, S., additional, Blanco, R., additional, González-Gay, M. A., additional, and López-Mejías, R., additional

Published
2021
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12. AB0094 INCREASE OF ENDOTHELIAL PROGENITOR CELLS IN SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE

Author

Pulito-Cueto, V., primary, Remuzgo Martinez, S., additional, Genre, F., additional, Atienza-Mateo, B., additional, Mora-Cuesta, V. M., additional, Iturbe-Fernández, D., additional, Lera-Gómez, L., additional, Pérez-Fernández, R., additional, Prieto-Peña, D., additional, Portilla, V., additional, Blanco, R., additional, Corrales, A., additional, Cifrián-Martínez, J. M., additional, López-Mejías, R., additional, and González-Gay, M. A., additional

Published
2021
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13. AB0026 DECREASE OF ANGIOGENIC T CELLS IN CONNECTIVE TISSUE DISEASE-ASSOCIATED INTERSTITIAL LUNG DISEASE

Author

Pulito-Cueto, V., primary, Remuzgo Martinez, S., additional, Genre, F., additional, Atienza-Mateo, B., additional, Mora-Cuesta, V. M., additional, Iturbe-Fernández, D., additional, Lera-Gómez, L., additional, Pérez-Fernández, R., additional, Alonso Lecue, P., additional, Rodriguez Carrio, J., additional, Prieto-Peña, D., additional, Portilla, V., additional, Blanco, R., additional, Corrales, A., additional, Cifrián-Martínez, J. M., additional, López-Mejías, R., additional, and González-Gay, M. A., additional

Published
2021
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14. AB0011 INFLUENCE OF IL17A GENE ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS

Author

Genre, F., primary, Remuzgo Martinez, S., additional, Pulito-Cueto, V., additional, Prieto-Peña, D., additional, Atienza-Mateo, B., additional, Sevilla, B., additional, Llorca, J., additional, Ortego, N., additional, Lera-Gómez, L., additional, Leonardo, M., additional, Peñalba, A., additional, Cabero, M. J., additional, Martín-Penagos, L., additional, Miranda-Filloy, J. A., additional, Navas Parejo, A., additional, De Argila, D., additional, Aragües, M., additional, Rubio-Romero, E., additional, Leon Luque, M., additional, Blanco-Madrigal, J. M., additional, Galindez, E., additional, Martin Ibanez, J., additional, Castañeda, S., additional, Blanco, R., additional, González-Gay ,,, M. A., additional, and López-Mejías, R., additional

Published
2020
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15. AB0012 ROLE OF IRF5 GENE ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS

Author

Remuzgo Martinez, S., primary, Genre, F., additional, Pulito-Cueto, V., additional, Prieto-Peña, D., additional, Atienza-Mateo, B., additional, Sevilla, B., additional, Llorca, J., additional, Ortego, N., additional, Lera-Gómez, L., additional, Leonardo, M., additional, Peñalba, A., additional, Cabero, M. J., additional, Martín-Penagos, L., additional, Miranda-Filloy, J. A., additional, Navas Parejo, A., additional, Sanchez Perez, J., additional, Aragües, M., additional, Rubio, E., additional, Leon Luque, M., additional, Blanco-Madrigal, J. M., additional, Galindez, E., additional, Martin Ibanez, J., additional, Castañeda, S., additional, Blanco, R., additional, González-Gay ,,, M. A., additional, and López-Mejías, R., additional

Published
2020
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16. SAT0014 ENDOTHELIAL PROGENITOR CELLS: ROLE IN ENDOTHELIAL DAMAGE OF INTERSTITIAL LUNG DISEASE ASSOCIATED TO RHEUMATOID ARTHRITIS

Author

Pulito-Cueto, V., primary, Remuzgo-Martínez, S., additional, Genre, F., additional, Mora-Cuesta, V. M., additional, Iturbe Fernández, D., additional, Fernández-Rozas, S., additional, Lera-Gómez, L., additional, Alonso Lecue, P., additional, Rodriguez Carrio, J., additional, Atienza-Mateo, B., additional, Portilla, V., additional, Merino, D., additional, Blanco, R., additional, Corrales, A., additional, Cifrián-Martínez, J. M., additional, López-Mejías, R., additional, and González-Gay, M. A., additional

Published
2020
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17. Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.

Author

Ortiz-Fernández L, Carmona EG, Kerick M, Lyons P, Carmona FD, López Mejías R, Khor CC, Grayson PC, Tombetti E, Jiang L, Direskeneli H, Saruhan-Direskeneli G, Callejas-Rubio JL, Vaglio A, Salvarani C, Hernández-Rodríguez J, Cid MC, Morgan AW, Merkel PA, Burgner D, Smith KG, Gonzalez-Gay MA, Sawalha AH, Martin J, and Marquez A

Subjects
Humans, CTLA-4 Antigen, Drug Repositioning, Genetic Predisposition to Disease genetics, Apoptosis Regulatory Proteins genetics, Systemic Vasculitis genetics, Vasculitis drug therapy, Vasculitis genetics
Abstract

Objectives: The number of susceptibility loci currently associated with vasculitis is lower than in other immune-mediated diseases due in part to small cohort sizes, a consequence of the low prevalence of vasculitides. This study aimed to identify new genetic risk loci for the main systemic vasculitides through a comprehensive analysis of their genetic overlap., Methods: Genome-wide data from 8467 patients with any of the main forms of vasculitis and 29 795 healthy controls were meta-analysed using ASSET. Pleiotropic variants were functionally annotated and linked to their target genes. Prioritised genes were queried in DrugBank to identify potentially repositionable drugs for the treatment of vasculitis., Results: Sixteen variants were independently associated with two or more vasculitides, 15 of them representing new shared risk loci. Two of these pleiotropic signals, located close to CTLA4 and CPLX1 , emerged as novel genetic risk loci in vasculitis. Most of these polymorphisms appeared to affect vasculitis by regulating gene expression. In this regard, for some of these common signals, potential causal genes were prioritised based on functional annotation, including CTLA4 , RNF145 , IL12B , IL5 , IRF1 , IFNGR1 , PTK2B , TRIM35 , EGR2 and ETS2 , each of which has key roles in inflammation. In addition, drug repositioning analysis showed that several drugs, including abatacept and ustekinumab, could be potentially repurposed in the management of the analysed vasculitides., Conclusions: We identified new shared risk loci with functional impact in vasculitis and pinpointed potential causal genes, some of which could represent promising targets for the treatment of vasculitis., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
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18. Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.

Author

Ortiz-Fernández L, Carmona FD, López-Mejías R, González-Escribano MF, Lyons PA, Morgan AW, Sawalha AH, Merkel PA, Smith KGC, González-Gay MA, and Martín J

Subjects
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis genetics, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis immunology, Case-Control Studies, Epigenesis, Genetic, Female, Genetic Loci immunology, Genetic Predisposition to Disease, Giant Cell Arteritis genetics, Giant Cell Arteritis immunology, HLA-DQ Antigens genetics, HLA-DQ Antigens immunology, HLA-DQ beta-Chains genetics, HLA-DQ beta-Chains immunology, Humans, Jumonji Domain-Containing Histone Demethylases immunology, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide, Protein Array Analysis, Systemic Vasculitis immunology, Takayasu Arteritis genetics, Takayasu Arteritis immunology, Genetic Loci genetics, Jumonji Domain-Containing Histone Demethylases genetics, Phenotype, Systemic Vasculitis genetics
Abstract

Objetive: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we performed the first cross-phenotype meta-analysis of genetic data from different clinically distinct patterns of vasculitis., Methods: Immunochip genotyping data from 2465 patients diagnosed with giant cell arteritis, Takayasu's arteritis, antineutrophil cytoplasmic antibody-associated vasculitis or IgA vasculitis as well as 4632 unaffected controls were analysed to identify common susceptibility loci for vasculitis development. The possible functional consequences of the associated variants were interrogated using publicly available annotation data., Results: The strongest association signal corresponded with an intergenic polymorphism located between HLA-DQB1 and HLA-DQA2 (rs6932517, P=4.16E-14, OR=0.74). This single nucleotide polymorphism is in moderate linkage disequilibrium with the disease-specific human leucocyte antigen (HLA) class II associations of each type of vasculitis and could mark them. Outside the HLA region, we identified the KDM4C gene as a common risk locus for vasculitides (highest peak rs16925200, P=6.23E-07, OR=1.75). This gene encodes a histone demethylase involved in the epigenetic control of gene expression., Conclusions: Through a combined analysis of Immunochip data, we have identified KDM4C as a new risk gene shared between systemic vasculitides, consistent with the increasing evidences of the crucial role that the epigenetic mechanisms have in the development of complex immune-mediated conditions., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)

Published
2018
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19. Investigation of a PON1 gene polymorphism (rs662 polymorphism) as predictor of subclinical atherosclerosis in patients with rheumatoid arthritis.

Author

López-Mejías R, Genre F, Corrales A, González-Juanatey C, Ubilla B, Llorca J, Miranda-Filloy JA, Pina T, Blanco R, Castañeda S, Martín J, and González-Gay MA

Subjects
Carotid Stenosis genetics, Gene Frequency, Humans, Polymorphism, Genetic, Arthritis, Rheumatoid genetics, Aryldialkylphosphatase genetics, Atherosclerosis genetics
Published
2014
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20. Antitumour necrosis factor α treatment reduces retinol-binding protein 4 serum levels in non-diabetic ankylosing spondylitis patients.

Author

Genre F, López-Mejías R, Miranda-Filloy JA, Ubilla B, Carnero-López B, Gómez-Acebo I, Blanco R, Ochoa R, Rueda-Gotor J, Pina T, González-Juanatey C, Llorca J, and González-Gay MA

Subjects
Diabetes Mellitus, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infliximab, Male, Tumor Necrosis Factor-alpha antagonists & inhibitors, Antibodies, Monoclonal therapeutic use, Antirheumatic Agents therapeutic use, Retinol-Binding Proteins, Plasma analysis, Spondylitis, Ankylosing blood, Spondylitis, Ankylosing drug therapy
Published
2014
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