1. Temporal trends in severe morbidity and mortality associated with ectopic pregnancy requiring hospitalisation in Washington State, USA: a population-based study
- Author
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Qi Wen, Mohamed A. Bedaiwy, Sarka Lisonkova, Lobna Abdellatif, Paul J. Yong, Sukainah Alfaraj, Lindsay L Richter, and Justin Tan
- Subjects
medicine.medical_treatment ,Logistic regression ,Severity of Illness Index ,0302 clinical medicine ,Pregnancy ,Obstetrics and Gynaecology ,Epidemiology ,Renal Insufficiency ,030212 general & internal medicine ,education.field_of_study ,Ectopic pregnancy ,Obstetrics ,Incidence ,Incidence (epidemiology) ,General Medicine ,Middle Aged ,Pregnancy, Ectopic ,3. Good health ,Hospitalization ,Intensive Care Units ,Maternal Mortality ,ectopic pregnancy ,Female ,epidemiology ,reproductive medicine ,Adult ,Washington ,medicine.medical_specialty ,Adolescent ,Pregnancy Complications, Cardiovascular ,Population ,Reproductive medicine ,Hysterectomy ,Young Adult ,03 medical and health sciences ,Sepsis ,medicine ,Humans ,Blood Transfusion ,education ,business.industry ,Research ,medicine.disease ,Comorbidity ,Logistic Models ,Uterine Hemorrhage ,Morbidity ,business ,Liver Failure ,030217 neurology & neurosurgery - Abstract
ObjectiveTo examine temporal trend in maternal mortality/severe morbidity associated with hospitalisation due to ectopic pregnancy.DesignA population-based observational study.Setting and participantsAll women hospitalised for ectopic pregnancy in Washington State, USA, 1987–2014 (n=20 418). The main composite outcome of severe morbidity/mortality included death, sepsis, need for transfusion, hysterectomy and systemic or organ failure, identified by diagnostic and procedure codes from hospitalisation files. Severe morbidity/mortality due to ectopic pregnancy were expressed as incidence ratios among women of reproductive age (15–64 years) and among women hospitalised for ectopic pregnancy. Comparisons were made between 1987–1991 (reference) and 2010–2014 using ratios of incidence ratios (RR) and ratio differences (RD). The Cochran-Armitage test for trend assessed statistical significance; logistic regression was used to obtain adjusted OR (AOR) and 95% CI, adjusted for demographic factors and comorbidity.ResultsHospitalisation for ectopic pregnancy declined from 0.89 to 0.16 per 1000 reproductive age women between 1987–1991 and 2010–2014 (pConclusionsHospitalisation for ectopic pregnancy declined in Washington State, USA, between 1987 and 2014; however, mortality/severe morbidity associated with ectopic pregnancy increased in female population aged 25–34 years.
- Published
- 2019