1. SARS-CoV-2 infection is associated with an increased risk of idiopathic acute pancreatitis but not pancreatic exocrine insufficiency or diabetes: long-term results of the COVIDPAN study
- Author
-
Ali Raza Haque, Altaf Awan, James Milburn, Simon Dwerryhouse, Javed Latif, Connor Magee, J. K. Pine, Dimitrios Karavias, Shameen Jaunoo, Chris Varghese, Nagappan Kumar, John A. Windsor, Rishi Singhal, Keith J. Roberts, Mary Phillips, Jeyakumar Apollos, Manu Nayar, Chetan Parmar, Venkat Kanakala, Husam Ebied, Guy Finch, Dhanny Gomez, Nehal Shah, Sanjay Pandanaboyana, Nilanjana Tewari, Krish Ravi, Kelvin Wang, Pierfrancesco Lapolla, Rami Benhmida, Marianne Hollyman, Aditya Kanwar, Clifford Caruana, Vasileios Charalampakis, Bogdan Ivanov, Tamsin Boyce, Ajith K. Siriwardena, Anita Balakrishnan, Zaigham Abbas, Cynthia-Michelle Borg, Semra Demirli Atici, Michael Okocha, Srinivasan Balachandra, Bilal Al-Sarireh, Michael Wilson, Christopher Halloran, Arab Rawashdeh, Jihène El Kafsi, Raimundas Lunevicius, James R A Skipworth, Maria V Coats, Nadeem A Ameer, and Dimitrios Damaskos
- Subjects
medicine.medical_specialty ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Gastroenterology ,Gallstones ,medicine.disease ,medicine.anatomical_structure ,Diabetes mellitus ,Internal medicine ,Cohort ,Etiology ,medicine ,Acute pancreatitis ,Pancreas ,business ,Body mass index - Abstract
We recently published in GUT the outcomes of acute pancreatitis (AP) and coexisting SARS-CoV-2 infection.1 A number of patients who were SARS-CoV-2 positive had AP of unknown aetiology (25%) speculating SARS-CoV-2 as a cause for AP similar to other viruses.2 However, most patients did not complete investigations to exclude other causes of AP. In addition, SARS-CoV-2 infection may cause aberrant glycometabolic control,3 however it is unknown if this increases the risk of long-term diabetes mellitus (DM). The follow-up data were collected 12 months from the date of recruitment for 1476 patients (118 patients who were SARS-CoV-2 positive and 1358 patients who were negative) to establish an aetiology for AP and development of DM. Among the 118 patients who were SARS-CoV-2 positive, 35 patients had idiopathic or unknown aetiology AP. Sixteen patients underwent either MRCP (n=13) or EUS (n=4) and the remaining patients underwent biochemical investigations to exclude other causes of AP. The final aetiology of AP was available for 83 (70.3%) patients and included gallstones (56, 47.4%), alcohol (19, 16.1%), post ERCP (2, 1.7%) and other (6, 5.1%). Overall, 23 patients had a change of aetiology, and in 35 (29.7%) patients AP was considered idiopathic. Patients who were SARS-CoV-2 positive were more likely to have idiopathic AP (34.7% vs 13.9%, p
- Published
- 2021