1. Association between the IL6-174G/C SNP and maximally attained lung function
- Author
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Catherine Derom, B. van den Borst, Ruth J. F. Loos, N Y Souren, Aimee D C Paulussen, Marij Gielen, Maurice P. Zeegers, Annemie M. W. J. Schols, Pulmonologie, Populatie Genetica, Complexe Genetica, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, and RS: NUTRIM - R4 - Gene-environment interaction
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,COPD ,biology ,business.industry ,Pulmonary disease ,Single-nucleotide polymorphism ,medicine.disease ,respiratory tract diseases ,Endocrinology ,Polymorphism (computer science) ,Internal medicine ,Immunology ,biology.protein ,Medicine ,SNP ,Allele ,business ,Interleukin 6 ,Lung function - Abstract
Recently, He et al 1 reported that the C allele of the interleukin 6 ( IL6 )-174G/C promoter polymorphism was associated with a rapid decline in forced expiratory volume in 1 s (FEV1) (≥3% predicted/year) and susceptibility to chronic obstructive pulmonary disease (COPD) in middle-aged smokers derived from three different cohorts.1 Alternatively, as also suggested by He et al in their discussion,1 we hypothesised that the IL6 -174G/C single nucleotide polymorphism (SNP) might not only affect the rate of lung function decline but also …
- Published
- 2010
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