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Background Primary biliary cirrhosis (PBC) is a cholestatic liver disease that may be complicated by osteoporosis whose etiology seems to be multifactorial. Objectives To determinate the frequency of bone diseases associated to PBC and to identify the independent risk factors correlated with osteoporosis during this hepatopathy. Methods A retrospective analysis of 66 patients (58 women and 8 men) was performed including all cases of PBC diagnosed between 1996 and 2010. Only patients who benefit from measurement of bone mineral density (BMD) were included. BMD was measured by DEXA at lomber (L2-L4) and femoral (femur neck) region. Measurement was expressed in two ways, one related to the peak bone mass (the T-score) and the other to the age-matched value (the Z-score). Both scores are expressed as the number of standard deviations by which BMD deviates from the mean value. Osteoporosis and osteopenia were defined as T score below or equal to -2,5 and between -2,5 and -1 respectively. Results BMD was performed in 32 patients (29 women and 3 men) aged from 19 to 73 years (mean age 52,5years). Only 8 patients had normal BMD (25%). Five patients had osteopenia. Osteoporosis was found in 19 patients (60%) including 17 women and 2 men meanly aged 59,9 years. Osteoporosis was revealed by a fracture in 3 cases. PBC developed since more than one year in 70% of cases. Among the fifteen postmenopausal women, 13 had osteoporosis, 2 had osteopenia and one had a normal BMD. Biological tests showed a cholestasis in all cases of osteoporosis and in 1 case of osteopenia. Phosphocalcic assessment was normal in all cases. Histological examination revealed an advanced stage (3 or 4) in 9 cases (47%) of osteoporosis and one case of osteopenia (25%). The research of another cause of osteoporosis was negative. In univariate analysis, no factor was significantly associated with the presence of osteoporosis. Conclusions Osteoporosis is a common complication of CBP where it appears to be related to the post menopausal state and the severity of liver disease. However, no factor was significantly associated with osteoporosis. Disclosure of Interest None Declared

Background Bone involvement is actually well demonstrated during chronic hepatopathies. Its frequency is not negligible and seems more frequent during auto-immune hepatopathies. Objectives To study bone mineral density profile of patients suffering from chronic hepathopathies and to establish characteristics of osteoporotic patients. Methods We carried a retrospective study from January 1996 to December 2009 including all cases of auto-immune hepatopathies [auto-immune hepatitis (AIH), primary biliary cirrhosis (PBC), Primary sclerosing cholangitis (PSC), Overlap syndrome PBC-AIH (OS1) and PSC-AIH (OS2)], diagnosed in the department of gastroenterology B in Rabta’s Hospital. We retained all patients having a bone densitometry (BD). Results During the period of the study, 85 patients were included. Thirty one had a BD: 20 PBC, 2 AIH, 7 OS1, 1 PSC, 1 OS2. BD was normal in 8 cases (25%): 5 PBC and 3 OS1. Osteopenia was reported in 6 cases (19.3%): 4PBC, 1 AIH and 1 OS1. Seventeen patients had osteoporosis (54%): 11 PBC, 1 AIH, 3 OS1, 1 PSC and 1 OS2. The mean T-score was (-3.35 DS) on lumbar spine and (-1.93 DS) on femur. The mean Z score was (-2.1 DS) on lumbar spine and (-0.7 DS) on femur. The mean age of osteoporotic patients was 56,8 years (extreme: 38-76 years). There were 16 women (94%) and one man. Among women, 13 were already postmenopausal (81%). Research of risk factors of osteoporosis revealed a corticotherapy in all cases of OS1 and smoking in 1 case (9% CBP). Biological tests showed transaminase 2-fold above normal values, in 8 cases (47%) with gammaglutamyl transpeptidase ≥5-fold above normal values in 6 patients (35%). The mean rate of bilirubin was 58 mg/l. The immunological tests revealed the presence of anti-mitochondrion-antibodies in 11 cases (9 PBC and 2 OS1), antinuclear-antibodies in 3 cases (2 OS1 and 1 AIH) and anti-smooth-muscle antibodies in 3 cases (2 OS1 and 1 AIH). Associated autoimmune manifestations were observed in 10 cases. A fibrosis degree ≥2 (according to Metavir score) was noted in 10 cases of which 6 were at the stage of cirrhosis at the time of the diagnosis (37%). Conclusions In our series, more than half of the patients with auto-immune liver diseases and having had a BD were osteoporotic. Bone loss is generally associated with PBC and is more frequent in postmenopausal women. Disclosure of Interest None Declared