1. Tumour-induced osteomalacia due to an intra-abdominal mesenchymal tumour
- Author
-
Anurag R. Lila, Tushar Bandgar, Brijesh Krishnappa, and Swati Ramteke Jadhav
- Subjects
Male ,Fibroblast growth factor 23 ,medicine.medical_specialty ,Serum albumin ,Parathyroid hormone ,Soft Tissue Neoplasms ,030209 endocrinology & metabolism ,030218 nuclear medicine & medical imaging ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Rare Disease ,Positron Emission Tomography Computed Tomography ,medicine ,Humans ,Osteomalacia ,biology ,business.industry ,Soft tissue ,General Medicine ,Middle Aged ,medicine.disease ,Fibroblast Growth Factor-23 ,Abdominal Neoplasms ,Positron-Emission Tomography ,Renal physiology ,biology.protein ,Histopathology ,medicine.symptom ,Nuclear medicine ,business - Abstract
A 50-year-man presented with debilitating lower-limb proximal muscle weakness and hip pain since 3 years. Investigations (serum calcium (8.9 mg/dL), serum phosphorus (1.5 mg/dL), serum albumin (40 g/L), parathyroid hormone (116 pg/mL (12.30 pmol/L)), 25(OH)D3 (25.2 ng/mL (63 nmol/L)) 1,25(OH)2 D3 (19 pg/mL (45.60 pmol/L)), tubular reabsorption of phosphate of 0.22 and elevated serum fibroblast growth factor 23 (FGF23) (387.7 RU/mL)) were consistent with tumour-induced osteomalacia (TIO). Localisation studies (68Ga DOTATATE positron emission tomography (PET)/CT and 18FDG-PET/CT) did not reveal any lesion. Re-evaluation after 2 and 5 years with 68Ga-DOTANOC PET/CT showed 2×1.4 cm progressively increasing rounded soft tissue enhancing mass close to splenic hilum (SUV max: 26.4). Tumour was resected by laparotomy. Both FGF23 (120 RU/mL on day 3) and serum phosphorus (2.5 mg/dL on day 10) normalised with significant clinical improvement after surgery. Histopathology revealed phosphaturic mesenchymal tumour. Here, we report the first case of intra-abdominal mesenchymal tumour causing TIO diagnosed by serial functional imaging.
- Published
- 2019
- Full Text
- View/download PDF