1. Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case-control study
- Author
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Xiaohua Tan, Jinquan Wang, Xianrong Xu, Xianhong Huang, Yinyin Wu, Yu Hong, Xiang Gao, Yifei Cao, Fuzhi Lian, and Lei Yang
- Subjects
Adult ,Male ,Aging ,China ,medicine.medical_specialty ,NUTRITION & DIETETICS ,Dietary factors ,Real-Time Polymerase Chain Reaction ,Logistic regression ,Hypertension risk ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Vegetables ,Epidemiology ,Leukocytes ,Odds Ratio ,EPIDEMIOLOGY ,Humans ,Medicine ,Telomere Shortening ,Aged ,Nutrition and Metabolism ,business.industry ,Research ,Case-control study ,Feeding Behavior ,General Medicine ,Odds ratio ,Middle Aged ,Telomere ,Diet ,Surgery ,Peripheral ,Logistic Models ,Case-Control Studies ,Hypertension ,Female ,business - Abstract
Objectives Peripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk. Study design A community-based case–control study. Participants 271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China. Outcome measures Peripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests. Results Among controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p
- Published
- 2015
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