1. Location specific rupture risk of intracranial aneurysms: case of ophthalmic aneurysms.
- Author
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Chiaroni PM, Guerra X, Cortese J, Burel J, Courret T, Constant Dit Beaufils P, Agripnidis T, Leonard-Lorant I, Fauché C, Bankole NDA, Forestier G, L'allinec V, Sporns PB, Gueton G, Lorena N, Psychogios MN, Girot JB, Rouchaud A, Janot K, Raynaud N, Pop R, Hak JF, Kerleroux B, Bourcier R, Marnat G, Papagiannaki C, Sourour NA, Clarençon F, and Shotar E more...
- Subjects
- Humans, Middle Aged, Female, Male, Aged, Retrospective Studies, Prospective Studies, Ophthalmic Artery diagnostic imaging, Cerebral Angiography, Risk Factors, Intracranial Aneurysm diagnostic imaging, Intracranial Aneurysm epidemiology, Aneurysm, Ruptured diagnostic imaging, Aneurysm, Ruptured epidemiology
- Abstract
Background: Aneurysm location is a key element in predicting the rupture risk of an intracranial aneurysm. A common impression suggests that pure ophthalmic aneurysms are under-represented in ruptured intracranial aneurysms (RIAs). The purpose of this study was to specifically evaluate the risk of rupture of ophthalmic aneurysms compared with other aneurysm locations., Methods: This multicenter study compared the frequency of ophthalmic aneurysms in a prospective cohort of RIAs admitted to 13 neuroradiology centers between January 2021 and March 2021, with a retrospective cohort of patients with unruptured intracranial aneurysms (UIAs) who underwent cerebral angiography at the same neuroradiology centers during the same time period., Results: 604 intracranial aneurysms were included in this study (355 UIAs and 249 RIAs; mean age 57 years (IQR 49-65); women 309/486, 64%). Mean aneurysm size was 6.0 mm (5.3 mm for UIAs, 7.0 mm for RIAs; P<0.0001). Aneurysm shape was irregular for 37% UIAs and 73% RIAs (P<0.0001). Ophthalmic aneurysms frequency was 14.9% of UIAs (second most common aneurysm location) and 1.2% of RIAs (second least common aneurysm location; OR 0.07 (95% CI 0.02 to 0.23), P<0.0001)., Conclusions: Ophthalmic aneurysms seem to have a low risk of rupture compared with other intracranial aneurysm locations. This calls for a re-evaluation of the benefit-risk balance when considering preventive treatment for ophthalmic aneurysms., Competing Interests: Competing interests: FC is a consultant for Medtronic, Balt Extrusion, Penumbra, Microvention, and Stryker; board member of Artedrone, and has stock options with Intradys and Collavidence. GM is a consultant for Stryker Neurovascular, Balt, Microvention Europe, and Sim and Cure, and has done paid lectures for Medtronic, Phenox, Johnson & Johnson, and Bracco. KJ is a consultant for Balt. AR is a consultant for Balt, Medtronic, Microvention, and Stryker. N-AS is a consultant for Balt, Medtronic Extrusion, and Microvention., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.) more...
- Published
- 2024
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