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7 results on '"Hax V"'

1. BIOELECTRICAL IMPEDANCE ANALYSIS SHOWED HIGH AGREEMENT AND SPECIFICITY TO ASSESSMENT OF LOW APPENDICULAR SKELETAL MUSCLE MASS IN WOMEN WITH SYSTEMIC SCLEROSIS: PRELIMINARY DATA.

Author

Denardi Dória, L., Do Espírito Santo, R. Cavalheiro, Hax, V., Santos, L., Pena, É., Mallmann, A. L., Pilotti, S., Moraes, D., Santos de Souza, T. J., Da Silva, B., Bosak, I., Lovison, V., Tessari, J. A., Jesus, P., Steinmetz, L., Legati, R., Espíndola Correia, P., Muniz Fighra, T., Gerchman, F., and Spritzer, P. M.

Published
2023
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7. Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis.

Author

Ariani A, Silva M, Bravi E, Parisi S, Saracco M, De Gennaro F, Caimmi C, Girelli F, De Santis M, Volpe A, Lumetti F, Hax V, Bredemeier M, Alfieri V, Santilli D, Bodini FC, Lucchini G, Mozzani F, Seletti V, Bacchini E, Arrigoni E, Giuggioli D, Chakr R, Idolazzi L, Bertorelli G, Imberti D, Michieletti E, Paolazzi G, Fusaro E, Chetta AA, Scirè CA, and Sverzellati N

Subjects
Aged, Biomarkers, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Prevalence, Prognosis, Pulmonary Emphysema diagnosis, Pulmonary Fibrosis diagnosis, Scleroderma, Systemic diagnosis, Tomography, X-Ray Computed, Pulmonary Emphysema complications, Pulmonary Emphysema mortality, Pulmonary Fibrosis complications, Pulmonary Fibrosis mortality, Scleroderma, Systemic complications, Scleroderma, Systemic mortality
Abstract

Objectives: This multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease-ILD, emphysema or neither)., Methods: Chest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Patients were clustered in four groups: SSc-CPFE, SSc-ILD, SSc-emphysema and other-SSc (without ILD nor emphysema). The overall mortality of these groups was calculated by Kaplan-Meier method and compared with the stratified log-rank test; Kruskal-Wallis test, t-Student test and χ² test assessed the differences between groups. P<0.05 was considered statistically significant., Results: We enrolled 470 patients (1959 patient-year); 15.5 % (73/470) died during the follow-up. Compared with the SSc-ILD and other-SSc, in SSc-CPFE there was a higher prevalence of males, lower anticentromere antibodies prevalence and a more reduced pulmonary function (p<0.05). The Kaplan-Meier survival analysis demonstrates a significantly worse survival in patients with SSc-CPFE (HR vs SSc-ILD, vs SSc-emphysema and vs other-SSc, respectively 1.6 (CI 0.5 to 5.2), 1.6 (CI 0.7 to 3.8) and 2.8 (CI 1.2 to 6.6)., Conclusions: CPFE increases the mortality risk in SSc along with a highly impaired lung function. These findings strengthen the importance to take into account emphysema in patients with SSc with ILD., Competing Interests: Competing interests: None declared.

Published
2019
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