4 results on '"Huayan Zhang"'
Search Results
2. Cohort protocol: Guangzhou High-Risk Infant Cohort study
- Author
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Huayan Zhang, Pian Hu, Azhu Han, Yuqi Wen, Jingjing Liang, Wanqi Xiao, Suifang Lin, Yanyan Song, Xuying Tan, Xiaopeng Zhao, Haipeng Dong, Qianyun Liu, and Li Tao
- Subjects
Medicine - Abstract
Introduction Despite the increase in the survival rate of high-risk infants (HRIs) worldwide, the prevalence of motor and neurodevelopmental sequelae in such newborns has not shown concomitant improvement. Meanwhile, there are few cohorts that explore factors related to the development of HRIs in China. Therefore, the Guangzhou High-Risk Infant Cohort (GHRIC) has been designed to examine the complex relationships among a myriad of factors influencing growth and development in such children.Methods and analysis The GHRIC study is a prospective cohort study that by the year 2023 will enrol an estimated total of 3000 HRIs from Guangzhou Women and Children’s Medical Center (GWCMC) in Guangzhou, China. This study is designed to assess the growth and cognitive characteristics of HRIs and the risk factors affecting their development and prognoses. Data on risk factors, neurodevelopmental and cognitive-function evaluations, laboratory results, and specimens will be collected and analysed. Information on perinatal and clinical interventions for these infants will also be recorded during regular follow-up visits until age 6.Ethics and dissemination The protocol for this study has been approved by the Research Ethics Committee of GWCMC, which accepted responsibility for supervising all of the aspects of the study (No. 2017102712). Study outcomes will be disseminated through conference presentations, peer-reviewed publications, the Internet and social media.Trial registration number ChiCTR-EOC-17013236
- Published
- 2020
- Full Text
- View/download PDF
3. Cohort protocol: Guangzhou High-Risk Infant Cohort study
- Author
-
Li Tao, Wanqi Xiao, Yuqi Wen, Huayan Zhang, Pian Hu, Yan Hu, Yuan Yuan, Jingjing Liang, Haipeng Dong, Yanyan Song, Azhu Han, Qianyun Liu, Suifang Lin, Xiaopeng Zhao, and Xuying Tan
- Subjects
medicine.medical_specialty ,China ,protocols & guidelines ,Epidemiology ,Psychological intervention ,neonatology ,Cohort Studies ,Pregnancy ,Risk Factors ,medicine ,Humans ,Neonatology ,Prospective Studies ,Prospective cohort study ,Child ,Survival rate ,Research ethics ,business.industry ,Infant, Newborn ,Infant ,General Medicine ,Research Design ,Family medicine ,Cohort ,Medicine ,Female ,business ,Cohort study - Abstract
IntroductionDespite the increase in the survival rate of high-risk infants (HRIs) worldwide, the prevalence of motor and neurodevelopmental sequelae in such newborns has not shown concomitant improvement. Meanwhile, there are few cohorts that explore factors related to the development of HRIs in China. Therefore, the Guangzhou High-Risk Infant Cohort (GHRIC) has been designed to examine the complex relationships among a myriad of factors influencing growth and development in such children.Methods and analysisThe GHRIC study is a prospective cohort study that by the year 2023 will enrol an estimated total of 3000 HRIs from Guangzhou Women and Children’s Medical Center (GWCMC) in Guangzhou, China. This study is designed to assess the growth and cognitive characteristics of HRIs and the risk factors affecting their development and prognoses. Data on risk factors, neurodevelopmental and cognitive-function evaluations, laboratory results, and specimens will be collected and analysed. Information on perinatal and clinical interventions for these infants will also be recorded during regular follow-up visits until age 6.Ethics and disseminationThe protocol for this study has been approved by the Research Ethics Committee of GWCMC, which accepted responsibility for supervising all of the aspects of the study (No. 2017102712). Study outcomes will be disseminated through conference presentations, peer-reviewed publications, the Internet and social media.Trial registration numberChiCTR-EOC-17013236
- Published
- 2020
4. Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials comparing transpyloric and gastric feeding.
- Author
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Jensen, Erik A., Huayan Zhang, Rui Feng, Dysart, Kevin, Nilan, Kathleen, Munson, David A., Kirpalani, Haresh, Zhang, Huayan, and Feng, Rui
- Subjects
TREATMENT of premature infant diseases ,RESEARCH ,CLINICAL trials ,RESEARCH methodology ,DISEASE incidence ,EVALUATION research ,MEDICAL cooperation ,COMPARATIVE studies ,RESEARCH funding ,ENTERAL feeding ,BRONCHOPULMONARY dysplasia ,CROSSOVER trials - Abstract
Objective: Compare rates of hypoxaemia during transpyloric and gastric feedings in very preterm infants with severe bronchopulmonary dysplasia.Design: N-of-1 multiple crossover trials with individual patient and pooled data analyses.Setting: Level IV intensive care nursery.Patients: Infants receiving positive airway pressure between 36 and 55 weeks postmenstrual age were enrolled between December 2014-July 2016.Intervention: N-of-1 trial consisting of two blocks, each with a 4-day gastric and 4-day transpyloric feeding period assigned in random order.Main Outcome Measures: The primary outcome was the frequency of daily intermittent hypoxaemic events (SpO2 ≤80% lasting 10-180 s). Secondary outcomes included the daily proportion of time with an SpO2 ≤80% and mean daily fraction of inspired oxygen.Results: Of 15 infants, 13 completed the trial and 2 stopped early for transient worsening in respiratory status during gastric feedings. In the intention-to-treat analyses, transpyloric feedings resulted in increased rates of intermittent hypoxaemia in five infants, greater time per day in hypoxaemia in three infants and more supplemental oxygen use in three infants. One infant received more supplemental oxygen during gastric feedings. The remaining study outcomes were similar between the feeding routes in all other infants. Pooling all data, transpyloric feedings resulted in a higher frequency of intermittent hypoxaemic events (median 7.5/day (IQR 1-23.5) vs 3/day (1-11); adjusted incidence rate ratio 1.8, 95% CI 1.3 to 2.5) and a greater proportion of daily hypoxaemia time (median 0.8% (IQR 0.1-2.3) vs 0.4% (0.07-1.8); adjusted mean difference 1.6, 95% CI 1.1 to 2.5).Conclusions: Transpyloric compared with gastric feedings modestly increased rates of hypoxaemia among study participants.Trial Registration Number: NCT02142621. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
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