10 results on '"Ives, Jonathan"'
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2. Protocol for establishing a child and adolescent twin register for mental health research and capacity building in Sri Lanka and other low and middleincome countries in South Asia.
- Author
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Jayaweera, Kaushalya, Craig, Jeffrey M., Zavos, Helena M. S., Abeysinghe, Nihal, De Alwis, Sunil, Andras, Alina, Dissanayake, Lasith, Dziedzic, Krysia, Fernando, Buddhika, Glozier, Nick, Hewamalage, Asiri, Ives, Jonathan, Jordan, Kelvin P., Kodituwakku, Godwin, Mallen, Christian, Rahman, Omar, Zafar, Shamsa, Saxena, Alka, Rijsdijk, Fruhling, and Saffery, Richard
- Abstract
Introduction Worldwide, 10%–20% of children and adolescents experience mental health conditions. However, most such disorders remain undiagnosed until adolescence or adulthood. Little is known about the factors that influence mental health in children and adolescents, especially in low and middle-income countries (LMIC), where environmental threats, such as poverty and war, may affect optimal neurodevelopment. Cohort studies provide important information on risks and resilience across the life course by enabling tracking of the effects of early life environment on health during childhood and beyond. Large birth cohort studies, including twin cohorts that can be aetiologically informative, have been conducted within high-income countries but are not generalisable to LMIC. There are limited longitudinal birth cohort studies in LMIC. Methods We sought to enhance the volume of impactful research in Sri Lanka by establishing a Centre of Excellence for cohort studies. The aim is to establish a register of infant, child and adolescent twins, including mothers pregnant with twins, starting in the districts of Colombo (Western Province) and Vavuniya (Northern Province). We will gain consent from twins or parents for future research projects. This register will provide the platform to investigate the aetiology of mental illness and the impact of challenges to early brain development on future mental health. Using this register, we will be able to conduct research that will (1) expand existing research capacity on child and adolescent mental health and twin methods; (2) further consolidate existing partnerships and (3) establish new collaborations. The initiative is underpinned by three pillars: high-quality research, ethics, and patient and public involvement and engagement (PPIE). Ethics and dissemination Ethical approval for this study was obtained from the Ethics Review Committee of Sri Lanka Medical Association and Keele University’s Ethical Review Panel. In addition to journal publications, a range of PPIE activities have been conducted. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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3. Position statement on ethics, equipoise and research on charged particle radiation therapy.
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Sheehan, Mark, Timlin, Claire, Peach, Ken, Binik, Ariella, Puthenparampil, Wilson, Lodge, Mark, Kehoe, Sean, Brada, Michael, Burnet, Neil, Clarke, Steve, Crellin, Adrian, Dunn, Michael, Fossati, Piero, Harris, Steve, Hocken, Michael, Hope, Tony, Ives, Jonathan, Kamada, Tadashi, John London, Alex, and Miller, Robert
- Subjects
THERAPEUTIC use of nuclear particles ,CLINICAL trials ,RADIOTHERAPY ,CANCER treatment ,ONCOLOGY - Abstract
The use of charged-particle radiation therapy (CPRT) is an increasingly important development in the treatment of cancer. One of the most pressing controversies about the use of this technology is whether randomised controlled trials are required before this form of treatment can be considered to be the treatment of choice for a wide range of indications. Equipoise is the key ethical concept in determining which research studies are justified. However, there is a good deal of disagreement about how this concept is best understood and applied in the specific case of CPRT. This report is a position statement on these controversies that arises out of a workshop held at Wolfson College, Oxford in August 2011. The workshop brought together international leaders in the relevant fields (radiation oncology, medical physics, radiobiology, research ethics and methodology), including proponents on both sides of the debate, in order to make significant progress on the ethical issues associated with CPRT research. This position statement provides an ethical platform for future research and should enable further work to be done in developing international coordinated programmes of research. [ABSTRACT FROM AUTHOR]
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- 2014
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4. Altruism in organ donation: an unnecessary requirement?
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Moorlock, Greg, Ives, Jonathan, and Draper, Heather
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ALTRUISM , *ORGAN donation , *PHILOSOPHICAL literature , *CONDUCT of life , *BIOETHICS , *SOCIAL attitudes - Abstract
Altruism has long been taken to be the guiding principle of ethical organ donation in the UK, and has been used as justification for rejecting or allowing certain types of donation. We argue that, despite this prominent role, altruism has been poorly defined in policy and position documents, and used confusingly and inconsistently. Looking at how the term has been used over recent years allows us to define 'organ donation altruism', and comparing this with accounts in the philosophical literature highlights its theoretical shortcomings. The recent report from the Nuffield Council on Bioethics reaffirmed the importance of altruism in organ donation, and offered a clearer definition. This definition is, however, more permissive than that of altruism previously seen in UK policy, and as a result allows some donations that previously have been considered unacceptable. We argue that while altruistic motivation may be desirable, it is not necessary. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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5. Doctors' willingness to give honest answers about end-of-life practices: a cross-sectional study.
- Author
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Merry, Alan F., Moharib, Magdi, Devcich, Daniel A., Webster, M. Louise, Ives, Jonathan, and Draper, Heather
- Abstract
Objectives: We aimed to (1) evaluate the extent to which doctors in New Zealand would be willing to answer honestly questions about their care of patients at the end of their lives and (2) identify the assurances that would encourage this. Results were compared with findings from a previous pilot study from the UK. Design: Survey study involving a mailed questionnaire. Setting: New Zealand hospital and community-based medical care settings. Participants: The questionnaire was mailed to a random sample of 800 doctors in New Zealand who were vocationally registered with the Medical Council of New Zealand in disciplines involving caring for patients at the end of their lives. Primary and secondary outcome measures: Willingness to provide honest answers about various aspects of end-of-life care; assurances that might increase willingness to provide honest answers to questions about end-of-life practices. Results: Completed questionnaires were returned by 436 doctors. The majority of respondents (59.9-91.5%) indicated willingness to provide honest answers to such questions. However, more than a third of doctors were unwilling to give honest answers to certain questions regarding euthanasia. These results are comparable with the UK data. Complete anonymity was the assurance most likely to encourage honest answering, with most of the respondents preferring the use of anonymous written replies. Respondents were less reassured by survey endorsements from regulatory bodies. Themes in free comments included the deterrent effect of medicolegal consequences, fear of censure from society, peers and the media and concerns about the motivations and potential uses of such research. Conclusions: Many New Zealand doctors were willing to give honest answers to questions about end-of-life practices, particularly if anonymity was guaranteed; others, however, expressed doubts or indicated that they would not be willing to provide honest answers to questions of this sort. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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6. PPI, paradoxes and Plato: who's sailing the ship?
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Ives, Jonathan, Damery, Sarah, and Redwod, Sabi
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MEDICAL care , *INTERPERSONAL relations , *SOCIAL change , *MENTAL health , *DECISION making - Abstract
Over the last decade, patient and public involvement (PPI) has become a requisite in applied health research. Some funding bodies demand explicit evidence of PPI, while others have made a commitment to developing PPI in the projects they fund. Despite being commonplace, there remains a dearth of engagement with the ethical and theoretical underpinnings of PPI processes and practices. More specifically, while there is a small (but growing) body of literature examining the effectiveness and impact of PPI, there has been relatively little reflection on whether the concept/practice of PPI is internally coherent. Here, the authors unpick a 'paradox' within PPI, which highlights a tension between its moral and pragmatic motivations and its implementation. The authors argue that this 'professionalisation paradox' means we need to rethink the practice, and purpose, of PPI in research. [ABSTRACT FROM AUTHOR]
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- 2013
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7. Ethical road map through the covid-19 pandemic: We must follow the ethics, not just the science.
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Fritz, Zoe, Huxtable, Richard, Ives, Jonathan, Paton, Alexis, Slowther, Anne Marie, and Wilkinson, Dominic
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- 2020
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8. Ethical road map through the pandemic: We must follow the ethics, not just the science.
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Fritz, Zoe, Huxtable, Richard, Ives, Jonathan, Paton, Alexis, Marie, Anne, and Wilkinson, Dominic
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ETHICS committees ,HEALTH services accessibility ,MEDICAL ethics ,HEALTH policy ,NATIONAL health services ,COVID-19 - Published
- 2020
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9. Clinicians and AI use: where is the professional guidance?
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Smith H, Downer J, and Ives J
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- Humans, Health Personnel ethics, State Medicine, Trust, Artificial Intelligence ethics, Decision Support Systems, Clinical
- Abstract
With the introduction of artificial intelligence (AI) to healthcare, there is also a need for professional guidance to support its use. New (2022) reports from National Health Service AI Lab & Health Education England focus on healthcare workers' understanding and confidence in AI clinical decision support systems (AI-CDDSs), and are concerned with developing trust in, and the trustworthiness of these systems. While they offer guidance to aid developers and purchasers of such systems, they offer little specific guidance for the clinical users who will be required to use them in patient care.This paper argues that clinical, professional and reputational safety will be risked if this deficit of professional guidance for clinical users of AI-CDDSs is not redressed. We argue it is not enough to develop training for clinical users without first establishing professional guidance regarding the rights and expectations of clinical users.We conclude with a call to action for clinical regulators: to unite to draft guidance for users of AI-CDDS that helps manage clinical, professional and reputational risks. We further suggest that this exercise offers an opportunity to address fundamental issues in the use of AI-CDDSs; regarding, for example, the fair burden of responsibility for outcomes., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.)
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- 2024
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10. Vaccine confidence, public understanding and probity: time for a shift in focus?
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Wheelock A and Ives J
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- Conflict of Interest, Humans, Pandemics prevention & control, Trust, Vaccination, COVID-19 prevention & control, Vaccines
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Lack of vaccine confidence can contribute to drops in vaccination coverage and subsequent outbreaks of diseases like measles and polio. Low trust in vaccines is attributed to a combination of factors, including lack of understanding, vaccine scares, flawed policies, social media and mistrust of vaccine manufacturers, scientists and decision-makers. The COVID-19 crisis has laid bare societies' vulnerability to new pathogens and the critical role of vaccines (and their acceptability) in containing this and future pandemics. It has also put science at the forefront of the response, with several governments relying on academics to help shape policy and communicate with the public. Against this backdrop, protecting public trust in scientists and scientific output is arguably more important than ever. Yet, conflicts of interest (CoI) in biomedical research remain ubiquitous and harmful, and measures to curb them have had limited success. There is also evidence of bias in industry-sponsored vaccine studies and academics are voicing concerns about the risks of working in a CoI prevalent research area. Here, we set out to challenge established thinking with regard to vaccine confidence, by shifting the gaze from a deficit in public understanding towards probity in research relationships and suggesting an alternative and perhaps complementary strategy for addressing vaccine mistrust. We argue that a concerted effort needs to be made to revisit the norms that undergird contemporary vaccine research, coupled with a willingness of all stakeholders to reimagine those relationships with an emphasis on demonstrating trustworthiness and probity., Competing Interests: Competing interests: AW received consultancy fees from Merck UK in 2018 and Sprout Behaviour Change in 2018-2019. JI received fees from UCB Pharma in 2019 for running ethics workshops., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
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