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Examines desmopressin and bleeding time in patients with cirrhosis. Effects of desmopressin acetate on shortening the bleeding time; Ability of concomitant administration of tranexamic acid in blocking increased fibrinolysis; Usability of desmopressin in correcting defects in hemostasis in chronic liver diseases.

Examines the progression of HIV diseases in a hemophilic cohort and the effect of treatment. Treatment with zidovudine or placebo; Symptoms of HIV infection, AIDS and death; Estimation of the rate of progression.

All 14 children who were conceived at the time their 12 haemophilic fathers were anti-HIV positive were shown to be HIV negative and to be healthy physically and mentally. Eleven of the 12 female partners have remained anti-HIV negative and one has seroconverted. Despite counselling it is likely that children will continue to be conceived by anti-HIV positive haemophiliacs. [ABSTRACT FROM AUTHOR]