1. Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis
- Author
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Carlo Alberto Scirè, Alarico Ariani, Mario Silva, Elena Bravi, Simone Parisi, Marta Saracco, Fabio De Gennaro, Cristian Caimmi, Francesco Girelli, Maria De Santis, Alessandro Volpe, Federica Lumetti, Vanessa Hax, Markus Bredemeier, Veronica Alfieri, Daniele Santilli, Flavio Cesare Bodini, Gianluca Lucchini, Flavio Mozzani, Valeria Seletti, Emanuele Bacchini, Eugenio Arrigoni, Dilia Giuggioli, Rafael Chakr, Luca Idolazzi, Giuseppina Bertorelli, Davide Imberti, Emanuele Michieletti, Giuseppe Paolazzi, Enrico Fusaro, Alfredo Antonio Chetta, and Nicola Sverzellati
- Subjects
Medicine - Abstract
Objectives This multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease—ILD, emphysema or neither).Methods Chest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Patients were clustered in four groups: SSc-CPFE, SSc-ILD, SSc-emphysema and other-SSc (without ILD nor emphysema). The overall mortality of these groups was calculated by Kaplan-Meier method and compared with the stratified log-rank test; Kruskal-Wallis test, t-Student test and χ² test assessed the differences between groups. P
- Published
- 2019
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