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IntroductionThe coronavirus pandemic has been particularly severe in the UK, with high infection and death rates, including among working age population.ObjectiveTo estimate occupational differences in COVID-19 mortality, taking into account confounding factors, such as regional differences, ethnicity, education, deprivation and pre-pandemic health.MethodsWe used data on 14,295,900 individuals who completed the UK Census in 2011, who were alive on 24 January 2020, were employed and aged 31–55 years in 2011. Data were linked to death and other health records. We examined differences between occupational groups in the risk of COVID-19 death from 24 January to 28 December 2020. We estimated age-standardised mortality rates per 100,000 person-years at risk stratified by sex and occupations. To estimate the effect of occupation due to work-related exposures, we used Cox proportional hazard models to adjust for confounding factors.ResultsThere is wide variation between occupations in COVID-19 mortality. Several occupations, particularly those involving contact with patients or the public, show three- or four-fold risks. These elevated risks were greatly attenuated after adjustment for confounding and mediating factors. For example, the hazard ratio (HR) for men working as taxi and cab drivers or chauffeurs changed from 4.60 [95%CI 3.62–5.84] to 1.47 [1.14–1.89] after adjustment. The overall HR for men working in essential occupations compared with men in non-essential occupations changed from 1.45 [1.34 - 1.56] to 1.22 [1.13 - 1.32] after adjustment. For most occupations, confounding and other mediating factors explained about 70% to 80% of the age-adjusted hazard ratios.ConclusionsWorking conditions are likely to play a role in COVID-19 mortality, particularly in occupations involving contact with COVID-19 patients or the public. However, there is also a substantial contribution from non-workplace factors, including regional factors, socio-demographic factors, and pre-pandemic health.