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What was classification as it first took modem form in the eighteenth century, and how did it relate to earlier ways of describing and ordering? We offer new answers to these questions by examining medicine rather than botany and by reconstructing practice on paper. First among disease classifications was the 'nosology' of the Montpellier physician Framjois Boissier de Sauvages de Lacroix. Analysis of his hitherto unstudied notebooks and of the nosology's many editions (1731-1772) shows that Boissier de Sauvages broke with earlier physicians' humanistic ordering of disease while sustaining the paper practices they had used. Scientific method was scholarly method. Classification arose through an incomplete break with, and intensified practice of, a past library-based way of ordering the described world. A new empiricism of generalizations (species) arose out of an older one of particulars (observationes). This happened through the rewriting - not the replacement - of the canon of disease knowledge since antiquity and its reordering on the printed page. [ABSTRACT FROM AUTHOR]