1. [Masked Philadelphia chromosome: diagnostic implications in a case of chronic myeloid leukemia presenting in blast crisis].
- Author
-
Carrasco JL, Hernández García MT, Otero A, Vilar MC, Marsá L, González Brito G, García Miranda JL, and Hernández Nieto L
- Subjects
- Aged, Blast Crisis pathology, Chromosomes, Human, Pair 22 ultrastructure, Chromosomes, Human, Pair 9 ultrastructure, Diagnosis, Differential, False Negative Reactions, Female, Gene Rearrangement, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology, Models, Genetic, Translocation, Genetic, Blast Crisis diagnosis, Karyotyping, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Leukemia, Myeloid, Acute diagnosis, Philadelphia Chromosome
- Abstract
We present a female patient with acute non-lymphoblastic leukemia (ANLL) and with haematologic features suggestive of its evolution from chronic myeloid leukaemia (CML), in which a bone marrow karyotype showing a "masked" Philadelphia (Ph) chromosome due to a variant translocation of complex type t(9;9;22)(q32;q34;q11) was found. We comment the peculiarities of this special Ph chromosome as well as the differential diagnostic problems between ANLL Ph(+) and CML with onset in blastic crisis.
- Published
- 1992