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1. Effect of NaF on rat tissue cAMP levels in vivo.

Author

Allmann DW and Kleiner HS

Subjects
Animals, Glucose metabolism, Injections, Intraperitoneal, Liver drug effects, Liver metabolism, Male, Rats, Sodium Fluoride administration & dosage, Cyclic AMP metabolism, Fluorides pharmacology, Sodium Fluoride pharmacology
Abstract

This investigation demonstrates that intraperitoneal injections of NaF (15 mg F/kg) results in hyperglycemia, inhibition of glycolysis, and an increase in tissue cAMP concentrations. Sodium fluoride significantly increases the cAMP concentration in liver, submaxillary gland, lung, heart, and kidney within 60 minutes following the injection.

Published
1980

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