1. Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
- Author
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Y. Manios, Peter Stehle, Manuel J. Castillo, Silvia Bel-Serrat, Esther M. González-Gil, Marcela González-Gross, Jin Young Park, Dénes Molnár, Antony Kafatos, Magdalena Cuenca-García, Mattias Sjöström, Frédéric Gottrand, Mathilde Kersting, Iris Iglesia, Francisco J. Sánchez-Muniz, L. A. Moreno, Javier Santabárbara, Kurt Widhalm, Ascensión Marcos, I. Huybrechts, Veronique Chajes, Theodora Mouratidou, S. De Henauw, Marika Ferrari, Abbott Fund, Ministerio de Ciencia e Innovación (España), European Commission, Instituto de Salud Carlos III, and Ministerio de Educación (España)
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Pyridoxal 5'-phosphate ,Adolescent ,Homocysteine ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Healthy Lifestyle in Europe by Nutrition in Adolescence ,Adolescents ,03 medical and health sciences ,chemistry.chemical_compound ,Folic Acid ,0302 clinical medicine ,S-Adenosyl-L-homocysteine ,B-vitamins ,Internal medicine ,Phosphatidylcholine ,HELENA ,S-adenosyl- l -homocysteine ,Humans ,Medicine ,Vitamin B12 ,Food science ,Fatty acids ,Child ,Phospholipids ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Plasma folate ,Fatty acid ,Diet quality index ,Health Surveys ,Europe ,Vitamin B 12 ,B vitamins ,tHcy homocysteine ,Endocrinology ,chemistry ,Female ,business ,Blood parameters ,Biomarkers ,Biomedical sciences - Abstract
On behalf of the HELENA Study Group., This study aimed to examine the association between vitamin B6, folate and vitamin B12 biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) and n-3 fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily, negative associations were found with n-6:n-3 ratio, trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all the associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin in females produces an increase of 15·85 Âmol/l of EPA (P value, The HELENA study received funding from the European Union’s Sixth RTD Framework Programme (contract FOODCT-2005-007034). Additional support was obtained from the Spanish Ministry of Education (AGL2007-29784-E/ALI), Axis-Shield Diagnostics Ltd (Oslo, Norway), Abbot Científica S.A. (Spain). This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) with the contribution of the European Regional Development Fund (FEDER). The first author is supported by a grant from the Spanish Carlos III Health Institute: RD08/0072/0025 (Red SAMID: Maternal, Child Health and Development Research Network).
- Published
- 2017