Search

Your search keyword '"Strelchuk, Daniela"' showing total 3 results
Start Over Author "Strelchuk, Daniela" Publisher cambridge university press
3 results on '"Strelchuk, Daniela"'

2. PTSD as a mediator of the relationship between trauma and psychotic experiences.

Author

Strelchuk, Daniela, Hammerton, Gemma, Wiles, Nicola, Croft, Jazz, Turner, Katrina, Heron, Jonathan, and Zammit, Stanley

Subjects
*CONFIDENCE intervals, *PSYCHOSES, *EMOTIONAL trauma, *POST-traumatic stress disorder, *RISK assessment, *DESCRIPTIVE statistics, *PARENT-child relationships, *LOGISTIC regression analysis, *ODDS ratio, *LONGITUDINAL method, *DISEASE complications, *CHILDREN, *ADULTS, *ADOLESCENCE
Abstract

Background: Traumatic experiences are associated with a higher risk of psychotic illnesses, but little is known about potentially modifiable mechanisms underlying this relationship. This study aims to examine whether post-traumatic stress disorder (PTSD) symptoms mediate the relationship between trauma and psychotic experiences (PEs). Methods: We used data from the Avon Longitudinal Study of Parents and Children to examine whether: PTSD symptoms mediate the relationships between (a) childhood trauma and adolescent PEs (study of adolescent PEs; n = 2952), and (b) childhood/adolescent trauma and PEs in early adulthood (study of adult PEs; n = 2492). We examined associations between variables using logistic regression, and mediation using the parametric g-computation formula. Results: Exposure to trauma was associated with increased odds of PEs (adolescent PEs: ORadjusted 1.48, 95% CI 1.23–1.78; adult PEs: ORadjusted 1.57, 95% CI 1.25–1.98) and PTSD symptoms (adolescent PTSD: ORadjusted 1.59, 95% CI 1.31–1.93; adult PTSD: ORadjusted 1.50, 95% CI 1.36–1.65). The association between PTSD symptoms and PE was stronger in adolescence (ORadjusted 4.63, 95% CI 2.34–9.17) than in adulthood (ORadjusted 1.62, 95% CI 0.80–3.25). There was some evidence that PTSD symptoms mediated the relationship between childhood trauma and adolescent PEs (proportion mediated 14%), though evidence of mediation was weaker for adult PEs (proportion mediated 8%). Conclusions: These findings are consistent with the hypothesis that PTSD symptoms partly mediate the association between trauma exposure and PEs. Targeting PTSD symptoms might help prevent the onset of psychotic outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

3. Reward sensitivity and waiting impulsivity: shift towards reward valuation away from action control : Impulsivity and reward

Author

Mechelmans, Daisy J, Strelchuk, Daniela, Donamayor-Alonso, Nuria, Banca, Paula, Robbins, Trevor W, Baek, Kwangyeol, and Voon, Valerie

Subjects
monetary incentive delay, supplementary motor area, impulsivity, orbitofrontal cortex, psychological phenomena and processes, reward
Abstract

Background Impulsivity and reward expectancy are commonly inter-related. Waiting impulsivity, measured using the rodent 5-Choice Serial Reaction Time (5-CSRT) task, predicts compulsive cocaine seeking and sign (or cue) tracking. Here we assess human waiting impulsivity using a novel translational task, the 4-CSRT, and the relationship with reward cues. Methods Healthy volunteers (n=29) performed the monetary incentive delay task as a functional MRI study where subjects observe a cue predicting reward (cue) and wait to respond for high (£5), low (£1) or no reward. Waiting impulsivity was tested with the 4-CSRT. Results For high reward prospects (£5 – no reward), greater waiting impulsivity on the 4-CSRT correlated with greater medial orbitofrontal cortex (OFC) and lower supplementary motor area (SMA) activity to cues. In response to high reward cues, greater waiting impulsivity was associated with greater subthalamic nucleus connectivity with OFC and greater subgenual cingulate connectivity with anterior insula but decreased connectivity with regions implicated in action selection and preparation. Conclusion These findings highlight a shift towards regions implicated in reward valuation and a shift towards compulsivity away from higher level motor preparation and action selection and response. We highlight the role of reward sensitivity and impulsivity, mechanisms potentially linking human waiting impulsivity with incentive approach and compulsivity, theories highly relevant to disorders of addiction. ispartof: International Journal of Neuropsychopharmacology vol:20 issue:12 pages:971-978 ispartof: location:England status: published

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results