1. Supplementation with methyl donors during lactation to high-fat-sucrose-fed dams protects offspring against liver fat accumulation when consuming an obesogenic diet
- Author
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Javier Campión, José Alfredo Martínez, Fermín I. Milagro, and Paul Cordero
- Subjects
DNA (Cytosine-5-)-Methyltransferase 1 ,Male ,medicine.medical_specialty ,Offspring ,Gene Expression ,Medicine (miscellaneous) ,Diet, High-Fat ,Choline ,chemistry.chemical_compound ,Folic Acid ,Dietary Sucrose ,Pregnancy ,Internal medicine ,Lactation ,medicine ,Animals ,Weaning ,Obesity ,RNA, Messenger ,Vitamin B12 ,Rats, Wistar ,integumentary system ,business.industry ,Fatty liver ,Maternal Nutritional Physiological Phenomena ,DNA Methylation ,medicine.disease ,humanities ,Diet ,Rats ,Betaine ,body regions ,Vitamin B 12 ,medicine.anatomical_structure ,Endocrinology ,Adipose Tissue ,Liver ,chemistry ,Dietary Supplements ,Body Composition ,Receptors, Leptin ,Female ,business - Abstract
Methyl donor supplementation has been reported to prevent obesity-induced liver fat accumulation in adult rats. We hypothesized that this protection could be mediated by perinatal nutrition. For this purpose, we assessed the response to an obesogenic diet (high-fat-sucrose, HFS) during adulthood depending on maternal diet during lactation. Female Wistar rats fed control diet during pregnancy were assigned to four postpartum dietary groups: control, control supplemented with methyl donors (choline, betaine, folic acid, vitamin B12), HFS and HFS supplemented with methyl donors. At weaning, the male offspring was transferred to a chow diet and at week 12th assigned to a control or a HFS diet during 8 weeks. The offspring whose mothers were fed HFS during lactation showed increased adiposity (19%,PPP
- Published
- 2014
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