1. Consumption of sucralose- and acesulfame-potassium-containing diet soda alters the relative abundance of microbial taxa at the species level: findings of two pilot studies.
- Author
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Sylvetsky, Allison C., Clement, Rebecca A., Stearrett, Nathaniel, Issa, Najy T., Dore, Fiona J., Mazumder, Raja, King, Charles Hadley, Hubal, Monica J., Walter, Peter J., Cai, Hongyi, Sen, Sabyasachi, Rother, Kristina I., and Crandall, Keith A.
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OBESITY , *BEVERAGES , *GUT microbiome , *BACTEROIDES , *WATER , *DIABETES , *SWEETENERS , *DIETARY sucrose , *ENTEROBACTERIACEAE , *COMPARATIVE studies , *CARBONATED beverages , *RESEARCH funding , *SECONDARY analysis , *BACTERIA , *ADIPOSE tissues , *ADULTS - Abstract
Sucralose and acesulfame-potassium consumption alters gut microbiota in rodents, with unclear effects in humans. We examined effects of three-times daily sucralose- and acesulfame-potassium-containing diet soda consumption for 1 (n = 17) or 8 (n = 8) weeks on gut microbiota composition in young adults. After 8 weeks of diet soda consumption, the relative abundance of Proteobacteria, specifically Enterobacteriaceae, increased; and, increased abundance of two Proteobacteria taxa was also observed after 1 week of diet soda consumption compared with sparkling water. In addition, three taxa in the Bacteroides genus increased following 1 week of diet soda consumption compared with sparkling water. The clinical relevance of these findings and effects of sucralose and acesulfame-potassium consumption on human gut microbiota warrant further investigation in larger studies. Clinical trial registration: NCT02877186 and NCT03125356. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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