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Your search keyword '"Vitaliano Tugnoli"' showing total 2 results
Start Over Author "Vitaliano Tugnoli" Publisher canadian science publishing
2 results on '"Vitaliano Tugnoli"'

1. 15N and 13C nuclear magnetic resonance of deoxydinucleotide monophosphates. II. Protonation of the homo dimers deoxycytidylyl-(3′,5′)-deoxycytidine, thymidylyl-(3′,5′)-thymidine, and deoxyadenylyl-(3′,5′)-deoxyadenosine in dimethyl sulfoxide

Author

Giovanna Barbarella, Luisa Tondelli, Massimo L. Capobianco, and Vitaliano Tugnoli

Subjects
chemistry.chemical_classification, Proton, Dimethyl sulfoxide, Stereochemistry, Organic Chemistry, Protonation, General Chemistry, Carbon-13 NMR, Phosphate, Catalysis, chemistry.chemical_compound, Hydrocarbon, Nuclear magnetic resonance, chemistry, Deoxyadenosine, Molecule
Abstract

The preferential protonation sites of the homo dimers deoxycytidylyl-(3′,5′)-deoxycytidine, thymidylyl-(3′,5′)-thymidine, and deoxyadenylyl-(3′,5′)-deoxyadenosine were established by nitrogen-15 and carbon-13 NMR in dimethyl sulfoxide, in the presence of varying amounts of CF3COOH. The nitrogen-15 NMR data show that in d(CpC) the capability of the two N3 nitrogens to accept the proton is slightly different. In d(TpT) and d(ApA) the protonation of the phosphate group leads to significant variations of the chemical shift of the carbons adjacent to phosphorus. Keywords: deoxydinucleotides, protonation, 15N and 13C NMR.

Published
1990
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2. 15N and 13C nuclear magnetic resonance of deoxydinucleotide monophosphates. I. Protonation of deoxycytidylyl-(3′,5′)-guanosine in dimethylsulfoxide

Author

Massimo L. Capobianco, Anna Garbesi, Giovanna Barbarella, Francesco Paolo Colonna, Vitaliano Tugnoli, and Antonio Carcuro

Subjects
Chemistry, Stereochemistry, Chemical shift, Organic Chemistry, Guanosine, Protonation, General Chemistry, Nuclear magnetic resonance spectroscopy, Medicinal chemistry, Catalysis, Sodium salt, chemistry.chemical_compound, Phosphate anion, CpG site, Chemical solution
Abstract

The 15N and 13C chemical shifts of the sodium salt of deoxycytidylyl-(3′,5′)-guanosine have been measured in dimethylsulfoxide in the presence of variable amounts of CF3COOH. N3(cyt) is protonated first, followed by N7(gua) and the phosphate anion. These results vary from those reported for the binding of the methylmercuric cation to d(CpG).

Published
1988
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