1. Passive protection of dogs against clinical disease due to Canine parvovirus-2 by specific antibody from chicken egg yolk
- Author
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Van Nguyen, Sa, Umeda, Kouji, Yokoyama, Hideaki, Tohya, Yukinobu, and Kodama, Yoshikatsu
- Subjects
Parvovirus, Canine ,animal diseases ,viruses ,Short Communications ,Immunization, Passive ,Antibodies, Viral ,Weight Gain ,Egg Yolk ,Virus Shedding ,Parvoviridae Infections ,Dogs ,Animals, Newborn ,Antibody Specificity ,Neutralization Tests ,Animals ,Dog Diseases ,Chickens - Abstract
The protective effect of immunoglobulins derived from chicken egg yolk (IgY) against infection by Canine parvovirus 2 (CPV-2) was evaluated in 10 beagle dogs orally challenged with a strain of the virus. The 2-mo-old dogs were divided into 3 groups and treated with powders containing CPV-2 IgY or normal egg yolk for 7 d after the challenge. The 4 dogs receiving normal egg yolk (control group) demonstrated mild symptoms typical of CPV-2 infection, such as vomiting, diarrhea, and weight loss. No symptoms were observed by 16 d after challenge in the 3 dogs receiving 2 g of IgY powder. Of the 3 dogs receiving 0.5 g of IgY powder, 2 had clinical CPV-2 disease; however, the manifestations were less severe than in the control group. Furthermore, the IgY-treated groups had significantly greater weight gain and shorter duration of virus shedding than the control group. These results indicate that IgY is useful in protecting dogs from CPV-2-induced clinical disease.
- Published
- 2006