1. Effect of oral anticoagulants on the outcome of faecal immunochemical test
- Author
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Maria Sala, JONE MIREN ALTZIBAR, Isabel Portillo, Manuel Hernandez-Guerra, Luis Bujanda, Maria Lopez-Ceron, Javier Pérez Gisbert, Francesc Macià, Vicent Hernandez, Xavier Bessa Caserras, Guillermo Cacho Acosta, Jaume Grau, Francesc Balaguer, JOAQUIN CUBIELLA, Cecilio Santander Vaquero, Leticia Moreira, Inmaculada Salces, Antoni Castells, Alicia C. Marin, Jose Diaz-Tasende, Jose m Enriquez-navascues, Blanca Rodriguez, Renata Linertová, Pablo Vega, Enrique Quintero, and Universitat de Barcelona
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Short Communication ,Population ,Colonoscopy ,colorectal cancer screening ,Gastroenterology ,law.invention ,Randomized controlled trial ,oral anticoagulant ,law ,Càncer colorectal ,Internal medicine ,medicine ,Humans ,Mass Screening ,education ,Early Detection of Cancer ,Mass screening ,Gynecology ,Aspirin ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Immunochemistry ,Anticoagulants ,Colonoscòpia ,Odds ratio ,Middle Aged ,FIT ,medicine.disease ,Clopidogrel ,faecal immunochemical test ,Immunoquímica ,Oncology ,Estudi de casos ,Occult Blood ,advanced neoplasia ,Anticoagulants (Medicina) ,Female ,Case studies ,Anticoagulants (Medicine) ,Colorectal Neoplasms ,business ,medicine.drug - Abstract
Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75¿ng¿ml–1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3–1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4–10.8; P=0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.
- Published
- 2014