1. Unique Roles of the Non-identical MCM Subunits in DNA Replication Licensing.
- Author
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Zhai, Yuanliang, Li, Ningning, Jiang, Hanlun, Huang, Xuhui, Gao, Ning, and Tye, Bik Kwoon
- Subjects
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PROTEIN precursors , *DNA replication , *HELICASES , *HOMOLOGOUS chromosomes , *ORIGIN recognition complex - Abstract
A family of six homologous subunits, Mcm2, -3, -4, -5, -6, and -7, each with its own unique features, forms the catalytic core of the eukaryotic replicative helicase. The necessity of six similar but non-identical subunits has been a mystery since its initial discovery. Recent cryo-EM structures of the Mcm2–7 (MCM) double hexamer, its precursors, and the origin recognition complex (ORC)-Cdc6-Cdt1-Mcm2–7 (OCCM) intermediate showed that each of these subunits plays a distinct role in orchestrating the assembly of the pre-replication complex (pre-RC) by ORC-Cdc6 and Cdt1. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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