1. Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis.
- Author
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Hershko AY, Suzuki R, Charles N, Alvarez-Errico D, Sargent JL, Laurence A, and Rivera J
- Subjects
- Animals, Chronic Disease, Dermatitis, Atopic chemically induced, Dermatitis, Atopic pathology, Immunoglobulin E immunology, Interleukin-2 deficiency, Interleukin-2 immunology, Mice, Mice, Knockout, Oxazolone, Spleen immunology, Dermatitis, Atopic immunology, Interleukin-2 biosynthesis, Mast Cells immunology
- Abstract
The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that mast cell-derived interleukin-2 (IL-2) contributes to the suppression of chronic allergic dermatitis. Mice deficient in IL-2 production, or deficient in mast cells (Kit(W-sh/W-sh)), showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type counterparts. Adoptive transfer of wild-type, but not Il2(-/-), mast cells into Kit(W-sh/W-sh) mice dampened the inflammatory response. During the course of disease, mast cell expansion occurred at the site of inflammation and also in the spleen, where production of IL-2 by mast cells was markedly enhanced. In the absence of mast cell IL-2 production, the ratio of activated to regulatory T cells at the site of inflammation was increased. Thus, MC-derived IL-2 contributes to the maintenance of suppression in chronic allergic skin inflammation., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
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