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3 results on '"Fosso, B."'

1. T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

Author

Perruzza, L, Gargari, G, Proietti, M, Fosso, B, D'Erchia, A, Faliti, C, Rezzonico-Jost, T, Scribano, D, Mauri, L, Colombo, D, Pellegrini, G, Moregola, A, Mooser, C, Pesole, G, Nicoletti, M, Norata, G, Geuking, M, Mccoy, K, Guglielmetti, S, Grassi, F, Perruzza L., Gargari G., Proietti M., Fosso B., D'Erchia A. M., Faliti C. E., Rezzonico-Jost T., Scribano D., Mauri L., Colombo D., Pellegrini G., Moregola A., Mooser C., Pesole G., Nicoletti M., Norata G. D., Geuking M. B., McCoy K. D., Guglielmetti S., Grassi F., Perruzza, L, Gargari, G, Proietti, M, Fosso, B, D'Erchia, A, Faliti, C, Rezzonico-Jost, T, Scribano, D, Mauri, L, Colombo, D, Pellegrini, G, Moregola, A, Mooser, C, Pesole, G, Nicoletti, M, Norata, G, Geuking, M, Mccoy, K, Guglielmetti, S, Grassi, F, Perruzza L., Gargari G., Proietti M., Fosso B., D'Erchia A. M., Faliti C. E., Rezzonico-Jost T., Scribano D., Mauri L., Colombo D., Pellegrini G., Moregola A., Mooser C., Pesole G., Nicoletti M., Norata G. D., Geuking M. B., McCoy K. D., Guglielmetti S., and Grassi F.

Abstract

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help.

Published
2017

2. T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.

Author

Perruzza L, Gargari G, Proietti M, Fosso B, D'Erchia AM, Faliti CE, Rezzonico-Jost T, Scribano D, Mauri L, Colombo D, Pellegrini G, Moregola A, Mooser C, Pesole G, Nicoletti M, Norata GD, Geuking MB, McCoy KD, Guglielmetti S, and Grassi F

Subjects
Animals, Body Weight, Glucose metabolism, Immunoglobulin A metabolism, Intestine, Small microbiology, Mice, Inbred C57BL, Receptors, Purinergic P2X7 deficiency, Receptors, Purinergic P2X7 metabolism, Adenosine Triphosphate metabolism, Extracellular Space metabolism, Gastrointestinal Microbiome immunology, Homeostasis, T-Lymphocytes, Helper-Inducer immunology
Abstract

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help., (Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2017
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3. BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity.

Author

Fransen F, Zagato E, Mazzini E, Fosso B, Manzari C, El Aidy S, Chiavelli A, D'Erchia AM, Sethi MK, Pabst O, Marzano M, Moretti S, Romani L, Penna G, Pesole G, and Rescigno M

Subjects
Animals, Bacteria classification, Bacteria genetics, Bacteria immunology, DNA, Bacterial chemistry, DNA, Bacterial genetics, Feces microbiology, Flow Cytometry, Host-Pathogen Interactions immunology, Immunization, Immunoglobulin A blood, Immunoglobulin A metabolism, Metagenomics methods, Mice, Inbred BALB C, Mice, Inbred C57BL, Microbiota genetics, Peyer's Patches immunology, Peyer's Patches metabolism, Peyer's Patches microbiology, Phylogeny, RNA, Ribosomal, 16S genetics, Salmonella typhimurium genetics, Salmonella typhimurium immunology, Salmonella typhimurium physiology, Species Specificity, Antigens, Bacterial immunology, Genetic Variation immunology, Immunoglobulin A immunology, Microbiota immunology
Abstract

The interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer's patches, independently of CX3CR1(+) phagocytes. This allowed the induction of bacteria-specific IgA and the establishment of a positive feedback loop of IgA production. Cohousing of mice or fecal transplantation had little or no influence on IgA production and had only partial impact on microbiota composition. Germ-free BALB/c, but not C57BL/6, mice already had polyreactive IgAs that influenced microbiota diversity and selection after colonization. Together, these data suggest that genetic predisposition to produce polyreactive IgAs has a strong impact on the generation of antigen-specific IgAs and the selection and maintenance of microbiota diversity., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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