1. Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection.
- Author
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Rogers KJ, Shtanko O, Vijay R, Mallinger LN, Joyner CJ, Galinski MR, Butler NS, and Maury W
- Subjects
- Animals, Female, Glycoproteins metabolism, Hemorrhagic Fever, Ebola prevention & control, Macrophages, Peritoneal pathology, Malaria parasitology, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptor, Interferon alpha-beta metabolism, Receptors, Interferon deficiency, Receptors, Interferon metabolism, Vesiculovirus physiology, Interferon gamma Receptor, Disease Resistance immunology, Ebolavirus physiology, Hemorrhagic Fever, Ebola complications, Hemorrhagic Fever, Ebola immunology, Interferon-gamma metabolism, Malaria complications, Plasmodium falciparum physiology
- Abstract
During the 2013-2016 Ebola virus (EBOV) epidemic, a significant number of patients admitted to Ebola treatment units were co-infected with Plasmodium falciparum, a predominant agent of malaria. However, there is no consensus on how malaria impacts EBOV infection. The effect of acute Plasmodium infection on EBOV challenge was investigated using mouse-adapted EBOV and a biosafety level 2 (BSL-2) model virus. We demonstrate that acute Plasmodium infection protects from lethal viral challenge, dependent upon interferon gamma (IFN-γ) elicited as a result of parasite infection. Plasmodium-infected mice lacking the IFN-γ receptor are not protected. Ex vivo incubation of naive human or mouse macrophages with sera from acutely parasitemic rodents or macaques programs a proinflammatory phenotype dependent on IFN-γ and renders cells resistant to EBOV infection. We conclude that acute Plasmodium infection can safeguard against EBOV by the production of protective IFN-γ. These findings have implications for anti-malaria therapies administered during episodic EBOV outbreaks in Africa., Competing Interests: Declaration of Interests The authors declare no competing interests., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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