Cross-coupling azide and isocyanide have recently gained recognition as ideal methods for efficiently synthesizing asymmetric carbodiimides. This reaction exhibits high reaction rates, efficiency, and favorable atom/step/redox economy. It enables the nitrene-transfer process, facilitating the formation of C-N bonds and providing a direct and cost-effective synthetic strategy for generating diverse carbodiimides. These carbodiimides are highly reactive compounds that can undergo in-situ transformations into various functional groups and organic compounds, including heterocycles. Developing one-pot and tandem processes in this field has significantly contributed to advancements in organic chemistry. Moreover, the demonstrated utility of these architectural motifs extends to areas such as chemical biology and medicinal chemistry, further highlighting their potential in various scientific applications., Competing Interests: The authors declare no competing interests., (© 2024 The Author(s).)