1. Molecular Basis of Disease Resistance and Perspectives on Breeding Strategies for Resistance Improvement in Crops.
- Author
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Deng, Yiwen, Ning, Yuese, Yang, Dong-Lei, Zhai, Keran, Wang, Guo-Liang, and He, Zuhua
- Abstract
Crop diseases are major factors responsible for substantial yield losses worldwide, which affects global food security. The use of resistance (R) genes is an effective and sustainable approach to controlling crop diseases. Here, we review recent advances on R gene studies in the major crops and related wild species. Current understanding of the molecular mechanisms underlying R gene activation and signaling, and susceptibility (S) gene-mediated resistance in crops are summarized and discussed. Furthermore, we propose some new strategies for R gene discovery, how to balance resistance and yield, and how to generate crops with broad-spectrum disease resistance. With the rapid development of new genome-editing technologies and the availability of increasing crop genome sequences, the goal of breeding next-generation crops with durable resistance to pathogens is achievable, and will be a key step toward increasing crop production in a sustainable way. In this perspective article, we summary recent progress on R gene isolation and the current understanding of the molecular mechanisms underlying R gene activation, and susceptibility (S) gene-mediated resistance in crops. Then we propose new strategies for R gene discovery, balancing resistance and yield in crop breeding toward improvement for disease resistance using new genome-editing technology. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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